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Titolo:
Acute ultrastructural effects of MPTP on the nigrostriatal pathway of the C57BL/6 adult mouse: Evidence of compensatory plasticity in nigrostriatal neurons
Autore:
Cochiolo, JA; Ehsanian, R; Bruck, DK;
Indirizzi:
San Jose State Univ, Dept Biol Sci, San Jose, CA 95192 USA San Jose State Univ San Jose CA USA 95192 iol Sci, San Jose, CA 95192 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 1, volume: 59, anno: 2000,
pagine: 126 - 135
SICI:
0360-4012(20000101)59:1<126:AUEOMO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN CATECHOLAMINE NEURONS; C57 BL/6 MICE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; DOPAMINERGIC NEUROTOXICITY; SUBSTANTIA NIGRA; CHRONIC PARKINSONISM; MONOAMINE-OXIDASE; STRIATAL DOPAMINE; MATURE MICE; MODEL;
Keywords:
electron microscopy; parkinsonism; Parkinson's disease; substantia nigra; striatum; dopaminergic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Bruck, DK San Jose State Univ, Dept Biol Sci, San Jose, CA 95192 USA San Jose State Univ San Jose CA USA 95192 an Jose, CA 95192 USA
Citazione:
J.A. Cochiolo et al., "Acute ultrastructural effects of MPTP on the nigrostriatal pathway of the C57BL/6 adult mouse: Evidence of compensatory plasticity in nigrostriatal neurons", J NEUROSC R, 59(1), 2000, pp. 126-135

Abstract

Acute doses of 1-methyt-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) elicited degenerative and apparently compensatory changes in the nigrostriatum of injected animals within 1 day of treatment. In the substantia nigra pars compacta (SNc), low-dose (20 mg/kg) administration elicited early degeneration of mitochondria in the absence of other effects. In the striatum, a low MPTP dose resulted in myelin unwinding, demyelination, cytoplasmic shrinkage, and disturbance of synaptic communication, as evinced by a profound reduction in synaptic vesicle production. High-dose (40 mg/kg) administration generated more drastic axonal degeneration leading to cell elimination in thestriatum. At neither dose was mitochondrial disturbance evident in the striatum. Evidence is presented that darkened synaptic boutons, visible at this level of MPTP administration, were part of healthy enlarged axons with anelevated number of synaptic contacts. These spared neuronal processes, therefore, were hypothesized to compensate for the MPTP-induced death of dopaminergic neurons by adaptive structural modifications that would serve to enhance their functional capability. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 07:03:58