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Titolo:
Evidence that brain-derived neurotrophic factor from presynaptic nerve terminals regulates the phenotype of calbindin-containing neurons in the lateral septum
Autore:
Fawcett, JP; Alonso-Vanegas, MA; Morris, SJ; Miller, FD; Sadikot, AF; Murphy, RA;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Inst, Montreal, PQ H3A 2B4, Canada McGill Univ, Ctr Neuronal Survival, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 ival, Montreal, PQ H3A 2B4, Canada McGill Univ, Div Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 20, anno: 2000,
pagine: 274 - 282
SICI:
0270-6474(20000101)20:1<274:ETBNFF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-RAT BRAIN; GROWTH-FACTOR; ANTEROGRADE TRANSPORT; PARKINSONS-DISEASE; FACTOR PROMOTES; MESSENGER-RNA; DOPAMINERGIC-NEURONS; CHOLINERGIC NEURONS; HIPPOCAMPAL-NEURONS; DENDRITIC GROWTH;
Keywords:
BDNF; calbindin; catecholaminergic neurons; septum; anterograde transport; TrkB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, RA McGill Univ, Montreal Neurol Inst, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQ Canada H3A 2B4 2B4, Canada
Citazione:
J.P. Fawcett et al., "Evidence that brain-derived neurotrophic factor from presynaptic nerve terminals regulates the phenotype of calbindin-containing neurons in the lateral septum", J NEUROSC, 20(1), 2000, pp. 274-282

Abstract

Brain-derived neurotrophic factor (BDNF) is transported anterogradely in neurons of the CNS and can be released by activity-dependent mechanisms to regulate synaptic plasticity. However, few neural networks have been identified in which the production, transport, and effects of BDNF on postsynapticneurons can be analyzed in detail. In this study, we have identified such a network. BDNF has been colocalized by immunocytochemistry with tyrosine hydroxylase (TH) in nerve fibers and nerve terminals within the lateral septum of rats. BDNF-containing nerve fibers terminate on a population of calbindin-containing neurons in lateral septum that contain TrkB, the high-affinity receptor for BDNF. Overexpression of BDNF in noradrenergic neurons increased levels of calbindin in septum, as well as in whole-brain lysates. Septal levels of calbindin and BDNF partially decreased after unilateral lesions of the medial forebrain bundle (MFB), induced with 6-hydroxydopamine, a treatment that abolished TH staining. These data suggest that BDNF is anterogradely transported within the MFB in catecholaminergic neurons arising from brainstem nuclei. To determine whether BDNF affects the production of calbindin in lateral septal neurons directly, we tested the effects of BDNF on cultures of septal neurons from embryonic day 16-17 rats. BDNF promoted the expression of calbindin, as well as the arborization of calbindin-containing neurons, but BDNF had no effect on cell division or survival. Together, these results suggest that BDNF, anterogradely transported in catecholaminergic neurons, regulates calbindin expression within the lateral septum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:08:14