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Titolo:
Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks
Autore:
Alkondon, M; Pereira, EFR; Eisenberg, HM; Albuquerque, EX;
Indirizzi:
Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Therapeut, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 t Neurosurg, Baltimore, MD 21201 USA Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Inst Ciencias Biomed, Dept Farmacol Basica & Clin, BR-21944 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21944 e Janeiro, Brazil
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 20, anno: 2000,
pagine: 66 - 75
SICI:
0270-6474(20000101)20:1<66:NRAIHC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL SLICES; DENTATE GRANULE CELLS; ACETYLCHOLINE-RECEPTORS; PARKINSONS-DISEASE; CIGARETTE-SMOKING; GABA RELEASE; HUMAN BRAIN; PHARMACOLOGICAL PROPERTIES; SYNAPTIC TRANSMISSION; ALZHEIMERS-DISEASE;
Keywords:
acetylcholine; choline; GABA; patch-clamp; methyllycaconitine; dihydro-beta-erythroidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Albuquerque, EX Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, 655 W Baltimore St, Baltimore, MD 21201 USA Univ Maryland 655 W Baltimore StBaltimore MD USA 21201 SA
Citazione:
M. Alkondon et al., "Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks", J NEUROSC, 20(1), 2000, pp. 66-75

Abstract

Cholinergic control of the activity of human cerebral cortical circuits has long been thought to be accounted for by the interaction of acetylcholine(ACh) with muscarinic receptors. Here we report the discovery of functional nicotinic receptors (nAChRs) in interneurons of the human cerebral cortexand discuss the physiological and clinical implications of these findings. The whole-cell mode of the patch-clamp technique was used to record responses triggered by U-tube application of the nonselective agonist ACh and of the alpha 7-nAChR-selective agonist choline to interneurons visualized by means of infrared-assisted videomicroscopy in slices of the human cerebral cortex. Choline induced rapidly desensitizing whole-cell currents that, being sensitive to blockade by methyllycaconitine (MLA; 50 nM), were most likely subserved by an alpha 7-like nAChR. In contrast, ACh evoked slowly decaying whole-cell currents that, being sensitive to blockade by dihydro-beta-erythroidine (DH beta E; 10 mu M), were most likely subserved by an alpha 4 beta 2-like nAChR. Application of ACh (but not choline) to the slices also triggered GABAergic postsynaptic currents (PSCs). Evidence is provided that ACh-evoked PSCs are the result of activation of alpha 4 beta 2-like nAChRs present in preterminal axon segments and/or in presynaptic terminals of interneurons. Thus, nAChRs can relay inhibitory and/or disinhibitory signals to pyramidal neurons and thereby modulate the activity of neuronal circuits in the human cerebral cortex. These mechanisms, which appear to be retainedacross species, can account for the involvement of nAChRs in cognitive functions and in certain neuropathological conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:18:20