Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Positive modulation of AMPA receptors increases neurotrophin expression byhippocampal and cortical neurons
Autore:
Lauterborn, JC; Lynch, G; Vanderklish, P; Arai, A; Gall, CM;
Indirizzi:
Univ Calif Irvine, Dept Anat & Neurobiol, Gillespie Neurosci Res Facil, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 sci Res Facil, Irvine, CA 92697 USA Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 & Human Behav, Irvine, CA 92697 USA Univ Calif Irvine, Dept Psychobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 pt Psychobiol, Irvine, CA 92697 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 20, anno: 2000,
pagine: 8 - 21
SICI:
0270-6474(20000101)20:1<8:PMOARI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; NERVE GROWTH-FACTOR; ACTIVITY-DEPENDENT REGULATION; TYROSINE KINASE RECEPTOR; DENTATE GRANULE CELLS; RAT VISUAL-CORTEX; SHORT-TERM-MEMORY; GLUTAMATE RECEPTORS; DIFFERENTIAL REGULATION; ALZHEIMERS-DISEASE;
Keywords:
brain-derived neurotrophic factor; nerve growth factor; ampakine; hippocampus; gene regulation; trkB; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Lauterborn, JC Univ Calif Irvine, Dept Anat & Neurobiol, Gillespie Neurosci Res Facil, Room 3226, Irvine, CA 92697 USA Univ Calif Irvine Room 3226 Irvine CA USA 92697 A 92697 USA
Citazione:
J.C. Lauterborn et al., "Positive modulation of AMPA receptors increases neurotrophin expression byhippocampal and cortical neurons", J NEUROSC, 20(1), 2000, pp. 8-21

Abstract

This study investigated whether positive modulators of AMPA-type glutamatereceptors influence neurotrophin expression by forebrain neurons. Treatments with the ampakine CX614 markedly and reversibly increased brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal slices. Acute effects of CX614 were dose dependent over the range in which the drug increased synchronous neuronal discharges; threshold concentrations for acute responses had large effects on mRNA content whenapplied for 3 d. Comparable results were obtained with a second, structurally distinct ampakine CX546. Ampakine-induced upregulation was broadly suppressed by AMPA, but not NMDA, receptor antagonists and by reducing transmitter release. Antagonism of L-type voltage-sensitive calcium channels blocked induction in entorhinal cortex but not hippocampus. Prolonged infusions of suprathreshold ampakine concentrations produced peak BDNF mRNA levels at 12 hr and a return to baseline levels by 48 hr. In contrast, BDNF protein remained elevated throughout a 48 hr incubation with the drug. Nerve growth factor mRNA levels also were increased by ampakines but with a much more rapid return to control levels during chronic administration. Finally, intraperitoneal injections of CX546 increased hippocampal BDNF mRNA levels in aged rats and middle-aged mice. The present results provide evidence of regional differences in mechanisms via which activity regulates neurotrophin expression. Moreover, these data establish that changes in synaptic potency produce sufficient network level physiological effects for inducing neurotrophin genes, indicate that the response becomes refractory during prolonged ampakine exposure, and raise the possibility of using positive AMPA modulators to regulate neurotrophin levels in aged brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:41:05