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Titolo:
The relationship between bone turnover and body weight, serum insulin-likegrowth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa
Autore:
Hotta, M; Fukuda, I; Sato, K; Hizuka, N; Shibasaki, T; Takano, K;
Indirizzi:
Tokyo Womens Med Univ, Sch Med, Dept Med, Inst Clin Endocrinol,Shinjuku Ku, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan Nippon Med Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138602, Japan Nippon Med Sch Tokyo Japan 1138602 siol, Bunkyo Ku, Tokyo 1138602, Japan
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 1, volume: 85, anno: 2000,
pagine: 200 - 206
SICI:
0021-972X(200001)85:1<200:TRBBTA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL-RAT CALVARIAE; SHORT-TERM; SOMATOMEDIN-C; HORMONE GH; NUTRITIONAL REGULATION; COLLAGEN DEGRADATION; WOMEN; OSTEOCALCIN; CHILDREN; OSTEOPOROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hotta, M Tokyo Womens Med Univ, Sch Med, Dept Med, Inst Clin Endocrinol,Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan Tokyo Womens Med Univ 8-1 Kawada Cho Tokyo Japan 1628666 , Japan
Citazione:
M. Hotta et al., "The relationship between bone turnover and body weight, serum insulin-likegrowth factor (IGF) I, and serum IGF-binding protein levels in patients with anorexia nervosa", J CLIN END, 85(1), 2000, pp. 200-206

Abstract

Malnutrition is one of the risk factors for bone loss in patients with anorexia nervosa (AN). To clarify the effects of nutritional status on bone metabolism, we examined the relationship between serum levels of nutritional indicators [insulin-like growth factor I (IGF-I), IGF-binding protein-2 (IGFBP-8), and IGFBP-3] and markers for bone metabolism [serum osteocalcin andurinary excretion of C-terminal telopeptide of collagen type I (CrossLaps)] in 45 AN out-patients, including 8 severely malnourished patients who required hospitalization and iv hyperalimentation (IVH). Compared to healthy subjects, serum IGF-I and IGFBP-3 were lower, whereas IGFBP-8 was higher in out-patients who had a body mass index (BMI) less than 16.5 kg/m(2). In these patients, urinary excretion of CrossLaps, a markerof bone resorption, was higher, whereas serum osteocalcin, a marker of bone formation, was lower than those in control subjects. All of these parameters were normal in patients whose BMI ranged from 16.5-18.5 kg/m(2). Serum levels of osteocalcin correlated positively with BMI (r = 0.512; P < 0.0001), IGF-I (r = 0.558; P < 0.0001), and IGFBP-3 (r = 0.369; P < 0.001) in AN out-patients. In the 8 severely malnourished AN patients, serum levels of IGF-I and osteocalcin significantly increased 3 and 7 days, respectively, after the start of a 6-week NH therapy regimen and reached normal levels within 5 weeks, accompanied by still elevated urinary excretion of CrossLaps. The present study demonstrates that an improvement in nutritional status in AN patients during NH therapy rapidly increases the serum IGF-I levels, followed by a progressive increase in osteocalcin, suggesting immediate start of bone formation. However, increased bone resorption appears to continuefor at least 5 weeks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:01:59