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Titolo:
Determination of flunarizine in rat brain by liquid chromatography-electrospray mass spectrometry
Autore:
Fuh, MR; Hsieh, CJ;
Indirizzi:
Soochow Univ, Dept Chem, Taipei, Taiwan Soochow Univ Taipei TaiwanSoochow Univ, Dept Chem, Taipei, Taiwan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 736, anno: 1999,
pagine: 167 - 173
SICI:
1387-2273(199912)736:1-2<167:DOFIRB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CINNARIZINE; METABOLISM;
Keywords:
flunarizine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Fuh, MR Soochow Univ, Dept Chem, POB 86-72, Taipei, Taiwan Soochow Univ POB 86-72 Taipei Taiwan , POB 86-72, Taipei, Taiwan
Citazione:
M.R. Fuh e C.J. Hsieh, "Determination of flunarizine in rat brain by liquid chromatography-electrospray mass spectrometry", J CHROMAT B, 736(1-2), 1999, pp. 167-173

Abstract

A rapid liquid chromatography-electrospray mass spectrometry (LC-ES-MS) assay for the determination of flunarizine (FZ) in rat brain has been developed. A C-18 column and an isocratic elution were employed for the separation. Using post-column split, 64% of the eluent was introduced into the ES-MS system for detection. The [M + H](+) (m/z 406) and a fragmented ion (m/z 203) were detected using selected ion monitoring. The linear range of this assay was good, ranging from 0.05 to 5 mu M (r(2) = 0.99). The intra- and inter-day precisions showed relative standard deviations ranging from 1.4% to 2.0% and 1.3% to 2.9%, respectively. The application of this newly developed method was demonstrated by examining the pharmacokinetics of FZ in rat brain. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/11/18 alle ore 03:28:46