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Titolo:
Use of recombinant human osteogenic protein-1 for the repair of subchondral defects in articular cartilage in goats
Autore:
Louwerse, RT; Heyligers, IC; Klein-Nulend, J; Sugihara, S; van Kampen, GPJ; Semeins, CM; Goei, SW; de Koning, MHMT; Wuisman, PIJM; Burger, EH;
Indirizzi:
ACTA Vrije Univ Amsterdam, Dept Oral Cell Biol, NL-1081 BT Amsterdam, Netherlands ACTA Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 BT , Netherlands Jan van Breemen Inst, Ctr Rheumatol & Rehabil, Amsterdam, Netherlands Jan van Breemen Inst Amsterdam Netherlands abil, Amsterdam, Netherlands Vrije Univ Amsterdam, Acad Hosp, Dept Orthopaed Surg, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands Surg, Amsterdam, Netherlands
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 4, volume: 49, anno: 1999,
pagine: 506 - 516
SICI:
0021-9304(19990315)49:4<506:UORHOP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTINUOUS PASSIVE MOTION; FULL-THICKNESS DEFECTS; IN-VITRO; DIFFERENTIATION; LESIONS; RABBIT; GRAFTS; OP-1;
Keywords:
cartilage; growth factors; tissue engineering; osteogenic protein-1; cartilage repair;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Burger, EH ACTA Vrije Univ Amsterdam, Dept Oral Cell Biol, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands ACTA Vrije Univ Amsterdam Van der Boechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
R.T. Louwerse et al., "Use of recombinant human osteogenic protein-1 for the repair of subchondral defects in articular cartilage in goats", J BIOMED MR, 49(4), 1999, pp. 506-516

Abstract

The objective of this pilot study was to examine in vivo the potential of recombinant human osteogenic protein-1 (rhOP-1, also called bone morphogenetic protein-7, BMP-7) for treatment of subchondral lesions by induction of new hyaline cartilage formation. Subchondral left knee defects in 17 maturegoats were treated with fresh coagulated blood mixed with (1) rhOP-1 combined with collagen (OP-1 device, 400 mu g/mL); (2) rhOP-1 alone (OP-1 peptide, 200 mu g/mL); (3) OP-1 device with small particles of autologous ear perichondrium; (4) OP-1 peptide with small particles of autologous ear perichondrium; or (5) autologous ear perichondrium alone (controls). rhOP-1 was combined with either collagen (OP-1 device) or not (OP-1 peptide). The defects were closed with a periosteal flay. The formation of cartilage tissue wasstudied by histologic and biochemical evaluation at 1, 2, and 4 months after implantation. One and 2 months after implantation there were no obvious differences between control and rhOP-1-treated defects. Four months after implantation, only one out of three controls (without rhOP-1) showed beginning signs of cartilage formation while all four rhOP-1-treated defects were completely or partly filled with cartilage. A significant linear relationship was found between rhOP-1 concentration and the total amount of aggrecan in the defects. These results suggest that implantation of rhOP-1 promotes cartilage formation in subchondral defects in goats at 4 months after implantation. Therefore, rhOP-1 could be a novel factor for regeneration of cartilage in articular cartilage defects. (C) 2000 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:57:56