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Titolo:
EFFECT OF TAUROHYODEOXYCHOLIC ACID ON BILIARY LIPID SECRETION IN HUMANS
Autore:
LORIA P; BOZZOLI M; CONCARI M; GUICCIARDI ME; CARUBBI F; BERTOLOTTI M; PIANI D; NISTRI A; ANGELICO M; ROMANI M; CARULLI N;
Indirizzi:
UNIV MODENA POLICLIN,DIPARTIMENTO MED INTERNA PATOL SPECIALE MED,VIA DEL POZZO 71 I-41100 MODENA ITALY UNIV MODENA,DIPARTIMENTO MED INTERNA I-41100 MODENA ITALY UNIV ROMA TOR VERGATA,DIPARTIMENTO SANITA PUBBL ROME ITALY OSPED CASTELFRANCO EMILIA,DIV CHIRURG MODENA ITALY
Titolo Testata:
Hepatology
fascicolo: 6, volume: 25, anno: 1997,
pagine: 1306 - 1314
SICI:
0270-9139(1997)25:6<1306:EOTAOB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MODEL BILE VESICLES; URSODEOXYCHOLIC ACID; HYODEOXYCHOLIC ACID; CHOLESTEROL GALLSTONES; CHENODEOXYCHOLIC ACID; INTESTINAL-ABSORPTION; RAT-LIVER; CHOLELITHIASIS; DISSOLUTION; PREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
P. Loria et al., "EFFECT OF TAUROHYODEOXYCHOLIC ACID ON BILIARY LIPID SECRETION IN HUMANS", Hepatology, 25(6), 1997, pp. 1306-1314

Abstract

This study aimed to determine the effect in humans of taurohyodeoxycholic acid, a 6 alpha-hydroxylated bile acid with hydrophilic properties, on bile lipid secretion, Four cholecystectomized patients who had gallstones and an interrupted enterohepatic circulation were intraduodenally infused with taurohyodeoxycholic and tauroursodeoxycholic acids on separate occasions at a dose of 0.8 to 1 g/h for 3 hours, In hourlybile samples collected for 8 hours after the beginning of the infusion, biliary bile acid composition (by high-performance liquid chromatography), biliary lipid concentrations (by standard methods), and distribution of biliary carriers (by gel chromatography) were evaluated, Blood liver function tests were performed before and after the infusions. Taurohyodeoxycholic and tauroursodeoxycholic acids became the predominant biliary bile acids in all patients except for one infused with taurohyodeoxycholic acid. Taurohyodeoxycholic acid stimulated significantly greater (P<.05) cholesterol and phospholipid secretion per unit ofsecreted bile acid (0.098 and 0.451 mu mol/mu mol, respectively) compared with tauroursodeoxycholic acid (0.061 mu mol/mu mol for cholesterol and 0.275 mu mol/mu mol for phospholipids). The secretory ratio between phospholipid and cholesterol was significantly higher after infusion of taurohyodeoxycholic acid (3.88 mu mol/mu mol) compared with taroursodeoxycholic acid (3.09 mu mol/pmol) (P<.05). Biliary enrichment with taurohyodeoxycholic acid was positively related with percent concentration of phospholipids but not with that of cholesterol, The opposite trend was observed in tauroursodeoxycholic acid-enriched biles. In both tauroursodeoxycholic acid- and tauroursodeoxycholic acid-rich bile, 80% to 90% of cholesterol was carried in a gel-chromatographic fraction corresponding to an apparent molecular weight of 80 to 200 kd. Noalteration in liver function test results was observed after taurohyodeoxycholic acid infusion, In conclusion, taurohyodeoxycholic acid stimulates greater cholesterol and phospholipid secretion than tauroursodeoxycholic acid, but with a higher phospholipid/cholesterol secretory ratio. In bile enriched with both bile acids, biliary cholesterol is transported in nonmicellar aggregates, Finally, in the conditions of our study, taurohyodeoxycholic acid was not hepatotoxic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 03:32:17