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Titolo:
Cord blood banking and transplantation - Fetal, maternal and perinatal issues
Autore:
Holzgreve, W; Surbek, DV;
Indirizzi:
Univ Basel, Frauenklin, CH-4031 Basel, Switzerland Univ Basel Basel Switzerland CH-4031 uenklin, CH-4031 Basel, Switzerland
Titolo Testata:
INFUSIONSTHERAPIE UND TRANSFUSIONSMEDIZIN
, volume: 26, anno: 1999, supplemento:, 2
pagine: 10 - 16
SICI:
1019-8466(199911)26:<10:CBBAT->2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; SEVERE COMBINED IMMUNODEFICIENCY; IN-UTERO TRANSPLANTATION; EFFICIENCY GENE-TRANSFER; PROGENITOR CELLS; PLACENTAL-BLOOD; BONE-MARROW; UNRELATED DONORS; GESTATIONAL-AGE; PRETERM INFANTS;
Keywords:
cord blood; stem cell transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Holzgreve, W Univ Basel, Frauenklin, Schanzenstr 46, CH-4031 Basel, Switzerland Univ Basel Schanzenstr 46 Basel Switzerland CH-4031 tzerland
Citazione:
W. Holzgreve e D.V. Surbek, "Cord blood banking and transplantation - Fetal, maternal and perinatal issues", INFUSIONSTH, 26, 1999, pp. 10-16

Abstract

Background: Umbilical cord blood is increasingly used as a source of hematopoietic stem cells for transplantation. While hematopoietic and immunologic properties of cord blood have been studied extensively, fetal, maternal and perinatal issues are yet to be explored. Material and Methods: We reviewed the currently available literature and our own studies concerning fetal and maternal issues in cord brood transplantation, including prenatal stem cell transplantation as well as the use of cord blood for autologous transfusion. Results: Prenatal and perinatal factors such as gestational age, fetal growth, or collection techniques have been shown to have a significant impact on the quantity and quality of cord blood. Ethical, legal and social questions begin to be defined. Prenatal stem cell transplantation has proven to be successful exclusively in immunodeficient fetuses. Early cord bloodstem cells might prove useful as target cells for in utero gene transfer aiming to cure nonimmunodeficient genetic diseases such as severe hemoglobinopathies before birth. Autologous transfusion in preterm neonates possibly provides a further new technique which makes use of the red blood cell compartment of cord blood. Conclusion: The emerging therapeutic use of cord blood for transplantation and transfusion implies new frontiers and challengesin fetomaternal medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:10:03