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Titolo:
Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats
Autore:
Leposavic, G; Plecas, B; Kosec, D;
Indirizzi:
Fac Pharm, Dept Physiol, YU-11221 Belgrade, Yugoslavia Fac Pharm Belgrade Yugoslavia YU-11221 ol, YU-11221 Belgrade, Yugoslavia Immunol Res Ctr Branislav Jankovic, YU-11221 Belgrade, Yugoslavia Immunol Res Ctr Branislav Jankovic Belgrade Yugoslavia YU-11221 goslavia
Titolo Testata:
IMMUNOPHARMACOLOGY
fascicolo: 1, volume: 46, anno: 2000,
pagine: 79 - 87
SICI:
0162-3109(200001)46:1<79:DEOCPT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC INNERVATION; POSITIVE SELECTION; THYMUS; CATECHOLAMINES; CELLS; EXPRESSION; HISTOFLUORESCENCE; IDENTIFICATION; MATURATION; HORMONES;
Keywords:
beta-adrenoceptors; propranolol treatment; rat thymus; T-cell maturation; sexual maturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Leposavic, G Fac Pharm, Dept Physiol, 450 Vojvode Stepe, YU-11221 Belgrade, Yugoslavia Fac Pharm 450 Vojvode Stepe Belgrade Yugoslavia YU-11221 via
Citazione:
G. Leposavic et al., "Differential effects of chronic propranolol treatment on the phenotypic profile of thymocytes from immature and adult rats", IMMUNOPHARM, 46(1), 2000, pp. 79-87

Abstract

To elucidate a putative role of beta-adrenoceptors in the modulation of intrathymic T-cell maturation, the expression of major differentiational antigene (CD4/CD8 and TCR alpha beta) on the thymocytes from both immature (aged 21 day at the beginning of the treatment) and adult (a,oed 75 days at thebeginning of treatment) male rats subjected to a 15-day-long propranolol treatment (0.40 mg/100 g/day, s.c.) was analyzed by two- and one-color flow cytometry, respectively. Rats of matched age injected with saline served ascontrols. The propranolol treatment in immature but not adult rats caused a significant reduction in both the relative thymus weight and total thymocyte yield. In addition, a significant increase in the percentage of CD4(+)8(+) double-positive cells, with a proportional decrease in the relative proportion of CD4(+)8(-) single positive cells, was found in immature rats. Incontrast, a slight but significant decrease in the percentage of CD4(+)8(+) cells with a parallel increase in the relative proportion of CD4+8- cellswas found in adult rats. In both groups of rats, the percentage of TCR alpha beta(total) thymocytes was increased: in immature rats this was due to an increase in the percentage of TCR alpha beta(low) thymocytes, while in the adult rats it reflected a rise in the relative proportion of TCR alpha beta(high) cells. In conclusion, the study revealed that propranolol treatment in both immature and adult rats alters the relative proportion of CD4(+)8(+) and CD4(+)8(-) thymocytes, but in opposite fashion, and the data suggest that this treatment affects distinct fractions within the population of CD4(+)8(+) thymocytes with respect to expression of TCR alpha beta. The results also indicate that, regardless of rat sexual maturity, the development of thymocytes towards CD4(-)8(+) T-cells is relatively insensitive to long-lasting P-adrenoceptor blockade. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:24:26