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Titolo:
Orally administered decoction of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To" modulates cytokine secretion and induces NKT cells in mouse liver
Autore:
Matsumoto, T; Sakurai, MH; Kiyohara, H; Yamada, H;
Indirizzi:
Kitasato Inst, Oriental Med Res Ctr, Minato Ku, Tokyo 1088642, Japan Kitasato Inst Tokyo Japan 1088642 s Ctr, Minato Ku, Tokyo 1088642, Japan
Titolo Testata:
IMMUNOPHARMACOLOGY
fascicolo: 2, volume: 46, anno: 2000,
pagine: 149 - 161
SICI:
0162-3109(200002)46:2<149:OADOK(>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICALLY ACTIVE SUBSTANCES; PECTIC POLYSACCHARIDE FRACTION; INTERFERON-GAMMA PRODUCTION; LYMPHOKINE SECRETION; ENDOTHELIAL CELLS; IMMUNE-RESPONSE; MURINE LIVER; RAT-LIVER; MICE; ACTIVATION;
Keywords:
Kampo medicines; th1-th2 balance; hepatic lymphocytes; Juzen-Taiho-To; NKT cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, H Kitasato Inst, Oriental Med Res Ctr, Minato Ku, 5-9-1 Shirokane,Tokyo 1088642, Japan Kitasato Inst 5-9-1 Shirokane Tokyo Japan 1088642 088642, Japan
Citazione:
T. Matsumoto et al., "Orally administered decoction of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To" modulates cytokine secretion and induces NKT cells in mouse liver", IMMUNOPHARM, 46(2), 2000, pp. 149-161

Abstract

The effects of orally administered decoction of Juzen-Taiho-To (JTT; Si-Quan-Da-Bu-Tang in Chinese) on cytokine production in hepatic lymphocytes were studied in mice. JTT was found to increase interferon gamma (IFN-gamma), as well as interleukin-4 (IL-4), IL-5 and IL-6 secretion from stimulated hepatic lymphocytes, whereas IL-2 secretion was reduced. The number of IFN-gamma- and IL-4-spot forming cells (SFC) were not changed by administration of JTT. These results suggest that modulation of cytokine secretion by JTT might not be due to changes in the number of cytokine secreting cells withinliver lymphocytes, CD4/CD8 ratio and alpha beta/gamma delta T cell, receptor (TCR) ratio in hepatic lymphocytes were not changed. However, flow cytometric analysis revealed that the population of CD3 positive intermediate cells in NK positive cells (NKT cells) was increased after oral administration of JTT. The population of CD3(int)IL-2R beta(+) cells was also increased. The induction of NKT cells by JTT was reduced by injection of 2-chloroadenosine. JTT enhanced transcription of IL-12 mRNA in Liver. From these results, it may be concluded that a rise in NKT cell population contributes, at least partially, to the modulating effect of JTT on cytokine production in liver lymphocytes, and macrophages. The production of IL-12 in liver may also contribute to this NKT induction. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:39:57