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Titolo:
Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions
Autore:
Chen, AI; McAdam, AJ; Buhlmann, JE; Scott, S; Lupher, ML; Greenfield, EA; Baum, PR; Fanslow, WC; Calderhead, DM; Freeman, GJ; Sharpe, AH;
Indirizzi:
Brigham & Womens Hosp, Dept Pathol, Div Immunol Res, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 munol Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Adult Oncol, Dana Farber Canc Inst, Boston, MA02115 USA Harvard Univ Boston MA USA 02115 na Farber Canc Inst, Boston, MA02115 USA Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA Harvard Univ BostonMA USA 02115 Sch Med, Dept Med, Boston, MA 02115 USA Immunex Res & Dev Corp, Seattle, WA 98101 USA Immunex Res & Dev Corp Seattle WA USA 98101 v Corp, Seattle, WA 98101 USA Dartmouth Med Sch, Lebanon, NH 03756 USA Dartmouth Med Sch Lebanon NH USA03756 uth Med Sch, Lebanon, NH 03756 USA
Titolo Testata:
IMMUNITY
fascicolo: 6, volume: 11, anno: 1999,
pagine: 689 - 698
SICI:
1074-7613(199912)11:6<689:OHACCR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; VASCULAR ENDOTHELIAL-CELLS; CONTACT HYPERSENSITIVITY; OX40 LIGAND; CYTOKINE PRODUCTION; IMMUNE-RESPONSES; INTERFERON-GAMMA; OX-40 LIGAND; MURINE; SENSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Sharpe, AH Brigham & Womens Hosp, Dept Pathol, Div Immunol Res, 75 FrancisSt, Boston, MA 02115 USA Brigham & Womens Hosp 75 Francis St Boston MA USA02115 115 USA
Citazione:
A.I. Chen et al., "Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions", IMMUNITY, 11(6), 1999, pp. 689-698

Abstract

The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential costimulatory molecule and also has been implicated in T cell homing and B cell activation. To ascertain the essential functions of Ox40L, we generated and characterized Ox40L-deficient mice. Mice lacking Ox40L exhibit an impaired contact hypersensitivity response, a dendriticcell-dependent T cell-mediated response, due to defects in T cell priming and cytokine production. In contrast, Ox40L-deficient mice do not have defects in T cell homing or humoral immune responses. In vitro, Ox40L-deficientdendritic cells are defective in costimulating T cell cytokine production. Thus, Ox40L has a critical costimulatory function in vitro and in vivo fordendritic cell:T cell interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:10:26