Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Contact-dependent hemolytic activity distinct from deforming activity of Bartonella bacilliformis
Autore:
Hendrix, LR;
Indirizzi:
Texas A&M Univ, Dept Med Microbiol & Immunol, Syst Hlth Sci Ctr, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 ci Ctr, College Stn, TX 77843 USA
Titolo Testata:
FEMS MICROBIOLOGY LETTERS
fascicolo: 1, volume: 182, anno: 2000,
pagine: 119 - 124
SICI:
0378-1097(20000101)182:1<119:CHADFD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROCYTE-MEMBRANES; DEFORMATION;
Keywords:
Carrion's disease; hemolysin; Bartonella bacilliformis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Hendrix, LR Texas A&M Univ, Dept Med Microbiol & Immunol, Syst Hlth Sci Ctr, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 ege Stn, TX 77843 USA
Citazione:
L.R. Hendrix, "Contact-dependent hemolytic activity distinct from deforming activity of Bartonella bacilliformis", FEMS MICROB, 182(1), 2000, pp. 119-124

Abstract

Although Bartonella bac bacilliformis causes a severe anemia in humans, this study presents the first report of hemolytic activity by B. bacilliformis. The activity was not apparent in culture supernatants but was reliably detected when B. bacilliformis cells were centrifuged onto erythrocytes prior to incubation. Abrogation of hemolytic activity by proteinase K treatmentsuggested the hemolysin was a Bartonella protein. Even though hemolysis required relatively long incubation times, de novo protein synthesis was not required to produce the protein. A preparation containing factors released by B. bacilliformis, including deformin, a B. bacilliformis protein able toinduce pits and invaginations in erythrocyte membranes, had some ability to lyse erythrocytes. However, pre-deformed erythrocytes did not lyse fasteror to a greater extent than control erythrocytes after the addition of B. bacilliformis cells. Inhibition of deformation caused by B. bacilliformis cells with the erythrocyte ATPase inhibitor, vanadate, did not affect hemolytic activity. This study suggests hemolytic activity and deforming activityare attributable to different B. bacilliformis proteins. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:16:36