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Titolo:
Major T cell epitope-containing peptides can elicit strong antibody responses
Autore:
Wu, B; Toussaint, G; Vander Elst, L; Granier, C; Jacquemin, MG; Saint-Remy, JMR;
Indirizzi:
Catholic Univ Louvain, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium Catholic Univ Louvain Louvain Belgium B-3000 ol, B-3000 Louvain, Belgium Univ Montpellier 1, CNRS, UMR 9921, Montpellier, France Univ Montpellier 1 Montpellier France RS, UMR 9921, Montpellier, France
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 1, volume: 30, anno: 2000,
pagine: 291 - 299
SICI:
0014-2980(200001)30:1<291:MTCEPC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELL; IMMUNE-RESPONSE; DERMATOPHAGOIDES-PTERONYSSINUS; MITE ALLERGEN; HLA-DR; P-II; ANTIGEN; SPECIFICITY; BINDING; MICE;
Keywords:
allergen peptide; Der p2; immunotherapy; T cell epitope; B cell epitope;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Saint-Remy, JMR Catholic Univ Louvain, Ctr Mol & Vasc Biol, Campus Gasthuisberg,O&N Herestr 49, B-3000 Louvain, Belgium Catholic Univ Louvain Campus Gasthuisberg,O&N Herestr 49 Louvain Belgium B-3000
Citazione:
B. Wu et al., "Major T cell epitope-containing peptides can elicit strong antibody responses", EUR J IMMUN, 30(1), 2000, pp. 291-299

Abstract

Peptides containing major T cell epitopes have the capacity to induce T cell anergy and have therefore been proposed for the treatment of allergic and autoimmune diseases. Such pep tides should not be immunogenic, i. e. should not contain a B cell recognition site. We have evaluated in BALB/c mice the therapeutic potential of a 15-mer peptide (p21-35) derived from Der p2,a major allergen of the house dust mite Dermatophagoides pteronyssinus, which contains a dominant T cell epitope but is not recognized by antibodies to Der p2. Unexpectedly, p21-35 elicited strong immune responses, suggesting the presence of a cryptic B cell epitope. Similar results were obtained with mice of three additional MHC haplotypes. A core sequence of four amino acids (Ile-lle-His-Arg) corresponding to residues 28-31 was shared by the Band T cell epitopes. Critical residues for B cell recognition were Arg31 and Lys33, while Ile28 was essential for T cell recognition. A Lys33Ala mutant of p21-35 still activated T cells but had much reduced immunogenic properties, making it a suitable alternative peptide for T cell anergy induction. Careful investigation of the immunogenic potential of peptides used to induce T cell anergy should be carried out prior to their clinical application.

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Documento generato il 02/12/20 alle ore 07:22:28