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Titolo:
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation
Autore:
Benoit, G; Altucci, L; Flexor, M; Ruchaud, S; Lillehaug, J; Raffelsberger, W; Gronemeyer, H; Lanotte, M;
Indirizzi:
Hop St Louis, Ctr G Hayem, INSERM, U496, F-75010 Paris, France Hop St Louis Paris France F-75010 m, INSERM, U496, F-75010 Paris, France ULP, CNRS, INSERM, IGBMC, F-67404 Illkirch, CU Strasbourg, France ULP Illkirch CU Strasbourg France F-67404 Illkirch, CU Strasbourg, France
Titolo Testata:
EMBO JOURNAL
fascicolo: 24, volume: 18, anno: 1999,
pagine: 7011 - 7018
SICI:
0261-4189(199912)18:24<7011:RRSITL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; TRANS-RETINOIC ACID; NUCLEAR-BODIES; NB4 CELLS; HISTONE DEACETYLASE; RESPONSE PATHWAYS; FUSION PROTEINS; RECEPTOR-LIGAND; MESSENGER-RNA; ALPHA;
Keywords:
differentiation; leukemia; nuclear receptors; protein kinase A; retinoids; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Gronemeyer, H Hop St Louis, Ctr G Hayem, INSERM, U496, 1 Ave Claude Vellefaux, F-75010 Paris, France Hop St Louis 1 Ave Claude Vellefaux Paris France F-75010 ce
Citazione:
G. Benoit et al., "RAR-independent RXR signaling induces t(15;17) leukemia cell maturation", EMBO J, 18(24), 1999, pp. 7011-7018

Abstract

Although retinoic acid receptor alpha (RAR alpha) agonists induce the maturation of t(15;17) acute promyelocytic leukemia (APL) cells, drug treatmentalso selects leukemic blasts expressing PML-RAR alpha fusion proteins withmutated ligand-binding domains that no longer respond to all-trans retinoic acid (ATRA). Here we report a novel RAR alpha-independent signaling pathway that induces maturation of both ATRA-sensitive and ATRA-resistant APL NB4 cells, and does not invoke the ligand-induced alteration of PML-RARa signaling, stability or compartmentalization. This response involves a cross-talk between RXR agonists and protein kinase A signaling. Our results indicate the existence of a separate RXR-dependent maturation pathway that can be activated in the absence of known ligands for RXR heterodimerization partners.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:49:56