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Titolo:
Differential expression of endothelial beta-catenin and plakoglobin duringdevelopment and maturation of the blood-brain and blood-retina barrier in the chicken
Autore:
Liebner, S; Gerhardt, H; Wolburg, H;
Indirizzi:
Univ Tubingen, Inst Pathol, D-7400 Tubingen, Germany Univ Tubingen Tubingen Germany D-7400 t Pathol, D-7400 Tubingen, Germany
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 1, volume: 217, anno: 2000,
pagine: 86 - 98
SICI:
1058-8388(200001)217:1<86:DEOEBA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-CATENIN; VE-CADHERIN; N-CADHERIN; TIGHT JUNCTIONS; CELL-ADHESION; PECTEN OCULI; RAT-BRAIN; PROTEIN; LOCALIZATION; UVOMORULIN;
Keywords:
blood-brain barrier; cell adhesion; tight junction; pericytes; chicken;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Wolburg, H Liebermeistrstr 8, D-72076 Tubingen, Germany Liebermeistrstr 8Tubingen Germany D-72076 Tubingen, Germany
Citazione:
S. Liebner et al., "Differential expression of endothelial beta-catenin and plakoglobin duringdevelopment and maturation of the blood-brain and blood-retina barrier in the chicken", DEV DYNAM, 217(1), 2000, pp. 86-98

Abstract

The development of the blood-brain barrier depends upon the formation of aclosely regulated system of adherens and tight junctions. A prerequisite for a functional junction system is the linkage of transmembrane adhesion receptors (cadherins) to the cytoskeleton via catenins, The localization of specific catenins at the adherens junction correlates with the stability of interendothelial contacts in vitro, but in vivo data are lacking thus far. Investigating brain angiogenesis in the chicken, we demonstrated that beta-catenin, but not plakoglobin, initially codistributed with N-cadherin at the ablumenal endothelial membrane at contact sites to perivascular cells, from where both antigens disappeared during blood-brain barrier maturation. In contrast, plakoglobin was most prominent at the interendothelial junctionwhere only small amounts of beta-catenin were present. Western-blot analysis revealed a stronger developmental decrease of beta-catenin than plakoglobin, whereas N-cadherin was completely lost. beta-Catenin but not N-cadherin was reinduced in brain endothelial cells during dedifferentiation in vitro and localized to the interendothelial junctions. These first in vivo datasupport the hypothesis that endothelial beta-catenin and N-cadherin are transiently relevant for the contact of brain endothelial to perivascular cells. Plakoglobin seems not to interact with N-cadherin but is exclusively localized at interendothelial junctions providing evidence for its role in the formation of stable adherens junctions, which may play a role for the initiation, and/or stabilization of tight junctions. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:30:36