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Titolo:
SILENT BRAIN INFARCTION ON MAGNETIC-RESONANCE-IMAGING AND NEUROLOGICAL ABNORMALITIES IN COMMUNITY-DWELLING OLDER ADULTS - THE CARDIOVASCULAR HEALTH STUDY
Autore:
PRICE TR; MANOLIO TA; KRONMAL RA; KITTNER SJ; YUE NC; ROBBINS J; ANTONCULVER H; OLEARY DH;
Indirizzi:
NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,6701 ROCKLEDGE DR,ROOM 8160 BETHESDA MD 20892 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV MARYLAND,MED CTR,DEPT NEUROL BALTIMORE MD 21201 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 JOHNS HOPKINS UNIV HOSP,DEPT NEURORADIOL BALTIMORE MD 21205 UNIV CALIF DAVIS,DEPT MED SACRAMENTO CA 95817 UNIV CALIF IRVINE,DIV EPIDEMIOL IRVINE CA 92717 TUFTS UNIV,MED CTR,DEPT RADIOL BOSTON MA 02111
Titolo Testata:
Stroke
fascicolo: 6, volume: 28, anno: 1997,
pagine: 1158 - 1164
SICI:
0039-2499(1997)28:6<1158:SBIOMA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL INFARCTION; ATRIAL-FIBRILLATION; ACUTE STROKE; RISK-FACTORS; DISEASE; PREVALENCE; MIGRAINE; LESIONS; MR;
Keywords:
CEREBRAL INFARCTION; COGNITION; ELDERLY; EPIDEMIOLOGY; MAGNETIC RESONANCE IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
T.R. Price et al., "SILENT BRAIN INFARCTION ON MAGNETIC-RESONANCE-IMAGING AND NEUROLOGICAL ABNORMALITIES IN COMMUNITY-DWELLING OLDER ADULTS - THE CARDIOVASCULAR HEALTH STUDY", Stroke, 28(6), 1997, pp. 1158-1164

Abstract

Background and Purpose Infarctlike lesions are frequently detected insymptomatic and asymptomatic older persons undergoing cerebral MRI, but their significance in older adults has not been examined. We determined the prevalence of MRI infarcts in a population-based sample of men and women aged greater than or equal to 65 years and related these findings to demographic, cognitive, and neurological status. Methods MRI scanning was performed in 3660 Cardiovascular Health Study (CHS) participants after brief neurological examinations and tests of cognitivefunction. MRIs were read centrally for the presence of an infarct greater than or equal to 3 mm in diameter or smaller infarctlike lesions. Results MRI infarcts were detected in 1131 of 3647 participants with readable infarct information (31%) and in 961 of the subgroup of 3397 participants (28%) without known prior stroke (''silent'' MRI infarcts). Smaller infarctlike lesions were found in 196 of 2516 participants who had no MRI infarcts greater than or equal to 3 mm. MRI infarcts were more common in participants who were older, had prior stroke, impaired cognition, visual field deficits, slowed repetitive finger tapping(all P < .0001), weakness on toe and heel walking, and history of memory loss, coma, or migraine headaches. Multivariate analysis in those without prier stroke showed strong associations of silent MRI infarctswith older age, history of migraines, lower digit symbol scores, and more abnormalities on neurological examination. Conclusions MRI evidence of brain infarction is common in older men and women without a clinical history of stroke. Their strong associations with impaired cognition and neurological deficits suggest that they are neither silent norinnocuous.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:07:42