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Titolo:
ISCHEMIC CEREBRAL INFARCTION AFTER RT-PA AND HEPARIN-THERAPY FOR ACUTE MYOCARDIAL-INFARCTION - THE TIMI-II PILOT AND RANDOMIZED CLINICAL-TRIAL COMBINED EXPERIENCE
Autore:
SLOAN MA; PRICE TR; TERRIN ML; FORMAN S; GORE JM; CHAITMAN BR; HODGES M; MUELLER H; ROGERS WJ; KNATTERUD GL; BRAUNWALD E;
Indirizzi:
MARYLAND MED RES INST,600 WYNDHURST AVE BALTIMORE MD 21210 UNIV MARYLAND,SCH MED,DEPT NEUROL BALTIMORE MD 21201 UNIV MASSACHUSETTS,SCH MED,DEPT MED WORCESTER MA 00000 ST LOUIS UNIV,MED CTR,DIV CARDIOL ST LOUIS MO 63110 UNIV MINNESOTA,DIV CARDIOL MINNEAPOLIS MN 00000 ALBERT EINSTEIN COLL MED,DIV CARDIOL NEW YORK NY 00000 UNIV ALABAMA,MED CTR,DEPT MED BIRMINGHAM AL 35294 HARVARD UNIV,SCH MED,DEPT MED,BRIGHAM & WOMENS HOSP BOSTON MA 00000 HARVARD UNIV,SCH MED,BETH ISRAEL HOSP BOSTON MA 00000
Titolo Testata:
Stroke
fascicolo: 6, volume: 28, anno: 1997,
pagine: 1107 - 1114
SICI:
0039-2499(1997)28:6<1107:ICIARA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY BYPASS; LEFT-VENTRICULAR THROMBI; STROKE-DATA-BANK; TWO-DIMENSIONAL ECHOCARDIOGRAPHY; TISSUE PLASMINOGEN-ACTIVATOR; THROMBOLYTIC THERAPY; INTRACEREBRAL HEMORRHAGE; CARDIAC SOURCE; CARDIOEMBOLIC STROKE; CEREBELLAR INFARCTS;
Keywords:
CEREBRAL INFARCTION; HEPARIN; MYOCARDIAL INFARCTION; THROMBOLYTIC THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
88
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Sloan et al., "ISCHEMIC CEREBRAL INFARCTION AFTER RT-PA AND HEPARIN-THERAPY FOR ACUTE MYOCARDIAL-INFARCTION - THE TIMI-II PILOT AND RANDOMIZED CLINICAL-TRIAL COMBINED EXPERIENCE", Stroke, 28(6), 1997, pp. 1107-1114

Abstract

Background and Purpose Ischemic cerebral infarction (CI) is a seriouscomplication of acute myocardial infarction (MI). Little information exists on CI after thrombolytic therapy for MI. Methods Of 3924 MI patients treated with recombinant tissue plasminogen activator (rt-PA) and heparin, 29 (0.7%) developed CI after treatment. All CI patients haddetailed neurological evaluations, and 27 (93%) had CT scans centrally reviewed. Results Age range was 40 to 74 years (mean, 60 years); 25 patients (86%) were men, and 22 (76%) were white. The electrocardiographic location of MI was anterior in 22 (76%) and nonanterior in 7 (24%). Five CIs occurred within 6 hours, 4 between 6 to 24 hours, 8 duringthe remainder of the first week, 10 during the second week, and 2 others distributed over the 4 weeks after study entry. Six of 29 CIs did not involve the cerebral cortex; 9 patients (31%) had multiple CIs. Of28 CIs thought to be embolic in origin, 17 showed strong evidence forat least one cardiac abnormality (mural clot, wall-motion abnormality, aneurysm, or atrial fibrillation) known to be associated more specifically with embolism than MI. Eight of 27 CIs (30%) with CT scans had hemorrhagic transformation of varying degrees; 5 were symptomatic. Conclusions The time of occurrence and sites of CI after rt-PA and heparin therapy for acute MT are similar to those reported during the prethrombolytic era.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:39:51