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Titolo:
Conventional ventilation modes with small pressure amplitudes and high positive end-expiratory pressure levels optimize surfactant therapy
Autore:
Verbrugge, SJC; Gommers, D; Lachmann, B;
Indirizzi:
Erasmus Univ, Dept Anesthesiol, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 12, volume: 27, anno: 1999,
pagine: 2724 - 2728
SICI:
0090-3493(199912)27:12<2724:CVMWSP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; HYALINE-MEMBRANE DISEASE; EXOGENOUS SURFACTANT; LUNG SURFACTANT; CONVERSION; RABBITS; INJURY; PLASMA;
Keywords:
mechanical ventilation; pulmonary surfactant; acute lung injury; blood gases; animal; rat; bronchoalveolar lavage; protein; phospholipids; positive end-expiratory pressure; inverse-ratio ventilation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lachmann, B Erasmus Univ, Dept Anesthesiol, Room Ee2393,POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Room Ee2393,POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
S.J.C. Verbrugge et al., "Conventional ventilation modes with small pressure amplitudes and high positive end-expiratory pressure levels optimize surfactant therapy", CRIT CARE M, 27(12), 1999, pp. 2724-2728

Abstract

Objective: High-frequency oscillation studies have shown that ventilation at high end-expiratory lung volumes combined with small volume cycles at high rates best preserves exogenous surfactant and gas exchange in lavaged lungs. We investigated whether surfactant composition and gas exchange can also be preserved by conventional modes of mechanical ventilation, which combine high levels of positive end-expiratory pressure (PEEP) with small pressure amplitudes. Design: Prospective, randomized, nonblinded, controlled study. Setting: Research laboratory. Subjects: Thirty male Sprague-Dawley rats. Interventions: Rats were lung-lavaged and treated with exogenous surfactant (100 mg/kg). After 5 mins, four different ventilator settings (FIO2 = 1.0) were applied for 3 hrs in four groups of rats [peak inspiratory pressure (cm H2O); static PEEP (cm H2O); inspiratory/expiratory ratio; frequency], as follows: 26/2/1:2/30 (group 26/2), 26/6/1:2/30 (group 26/6), 20/10/1:2/30(group 20/10-static), and 20/6/7:3/130, creating an auto PEEP of 4 cm H2O (group 20/10-auto). Measurements and Main Results: In all groups, PaO2 increased immediately to prelavage values after surfactant therapy. In group 26/2, PaO2 deteriorated to postlavage values within 30 mins when PEEP was decreased to 2 cm H2O,whereas PaO2 remained stable for 3 hrs in the other groups, The PaCO2 increased in groups 26/2 and 20/10-static; PaCO2 could not be reduced by increasing ventilation frequency to 130 in group 20/10-static. Groups 26/6 and 20/10-auto remained normocapnic. Bronchoalveolar lavage protein concentrationwas higher in groups 26/2 and 26/6 compared with groups 20/10-static and 20/10-auto. There was significantly more conversion of surface active large aggregates into nonactive small aggregates in group 26/2 compared with groups 28/10-static and 20/10-auto. Conclusions: We conclude that exogenous surfactant composition is preserved by conventional modes of mechanical ventilation that use small pressure amplitudes, and adequate oxygenation is maintained by high end-expiratory pressure levels. Effective carbon dioxide removal can be achieved by applyinga ventilation mode that creates auto PEEP and not by a mode that applies the same level of PEEP by static PEEP only.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:38:55