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Titolo:
Evaluation of standardized uptake value to assess cerebral glucose metabolism
Autore:
Yamaji, S; Ishii, K; Sasaki, M; Mori, T; Kitagaki, H; Sakamoto, S; Mori, E;
Indirizzi:
Hyogo Inst Aging Brain & Cognit Disorders, Div Imaging Res, Himeji, Hyogo 3700981, Japan Hyogo Inst Aging Brain & Cognit Disorders Himeji Hyogo Japan 3700981 apan Hyogo Inst Aging Brain & Cognit Disorders, Div Imaging Res & Clin Neurosci, Himeji, Hyogo 3700981, Japan Hyogo Inst Aging Brain & Cognit Disorders Himeji Hyogo Japan 3700981 apan Hyogo Ctr Adults, Dept Radiol, Akashi, Hyogo, Japan Hyogo Ctr Adults Akashi Hyogo Japan s, Dept Radiol, Akashi, Hyogo, Japan
Titolo Testata:
CLINICAL NUCLEAR MEDICINE
fascicolo: 1, volume: 25, anno: 2000,
pagine: 11 - 16
SICI:
0363-9762(200001)25:1<11:EOSUVT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ALZHEIMERS-DISEASE; FDG-PET; DIFFERENTIAL-DIAGNOSIS; INPUT FUNCTION; DEMENTIA; FLUORODEOXYGLUCOSE; HYPOMETABOLISM; HUMANS;
Keywords:
Alzheimer's disease; cerebral glucose metabolism; fluorine-18 fluorodeoxyglucose; positron emission tomography; standardized uptake value;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ishii, K Hyogo Inst Aging Brain & Cognit Disorders, Div Imaging Res, 520 Saisho Ko,Himeji, Hyogo 3700981, Japan Hyogo Inst Aging Brain & Cognit Disorders 520 Saisho Ko Himeji Hyogo Japan 3700981
Citazione:
S. Yamaji et al., "Evaluation of standardized uptake value to assess cerebral glucose metabolism", CLIN NUCL M, 25(1), 2000, pp. 11-16

Abstract

Purpose: When the cerebral metabolic rate of glucose (CMRglc) is to be measured, arterial blood sampling is usually required for fluorine-18 fluorodeoxyglucose (FDG) and positron emission tomography (PET) studies. However, blood sampling is inconvenient because it requires several staff members andis invasive for patients. Methods: To assess cerebral glucose metabolism by a noninvasive and simplified method, the authors used the standardized uptake value (SUV), which requires no input function or blood sampling. The study participants included18 healthy volunteers (4 men and 14 women; mean +/- SD age, 68.2 +/- 6.3 years), 18 patients with mild Alzheimer's disease (AD) (4 men and 14 women; mean a SD age, 68.8 +/- 7.3 years), and 18 patients with moderate AD (5 menand 13 women, mean +/- SD age, 69.5 +/- 8.5 years). Regional CMRglc and regional cerebral SUV were measured in the three groups using FDG PET, and the correlation between global CMRglc and global SUV was estimated. Results: The correlation coefficients of global CMRglc and global SUV in the healthy volunteers, mild AD patients, and moderate AD patients were 0.82, 0.67, and 0.62, respectively. Compared with the healthy persons, the patients with mild AD showed significantly decreased CMRglc in the temporal, frontal, and parietal cortices, but they did not show significantly decreasedSUV in any region. Patients with moderate AD had significantly decreased CMRglc in the temporal, frontal, occipital, parietal, and sensorimotor cortices and significantly decreased SUV in the temporal, frontal, occipital, and parietal cortices. Conclusion: The SUV would be useful as a semiquantitative index of cerebral glucose metabolism only in healthy persons or those with mild AD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:11:19