Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Visual contrast response functions in Parkinson's disease: evidence from electroretinograms, visually evoked potentials and psychophysics
Autore:
Langheinrich, T; van Elst, LT; Lagreze, WA; Bach, M; Lucking, CH; Greenlee, MW;
Indirizzi:
Univ Freiburg, Neurol Klin, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 l Klin, D-79106 Freiburg, Germany Univ Freiburg, Psychiat Klin, Freiburg, Germany Univ Freiburg Freiburg Germany eiburg, Psychiat Klin, Freiburg, Germany Univ Freiburg, Augenklin, D-7800 Freiburg, Germany Univ Freiburg Freiburg Germany D-7800 ugenklin, D-7800 Freiburg, Germany
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 1, volume: 111, anno: 2000,
pagine: 66 - 74
SICI:
1388-2457(200001)111:1<66:VCRFIP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATTERN ELECTRORETINOGRAMS; SYNAPTIC ORGANIZATION; DOPAMINE DEFICIENCY; SENSITIVITY; MONKEY; RETINA; CAT; CORTEX; DYSFUNCTION; CELLS;
Keywords:
contrast discrimination; electroretinogram; visual evoked potentials; Parkinson's disease; neurodegenerative diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Greenlee, MW Univ Freiburg, Neurol Klin, Breisacherstr 64, D-79106 Freiburg, Germany Univ Freiburg Breisacherstr 64 Freiburg Germany D-79106 many
Citazione:
T. Langheinrich et al., "Visual contrast response functions in Parkinson's disease: evidence from electroretinograms, visually evoked potentials and psychophysics", CLIN NEU, 111(1), 2000, pp. 66-74

Abstract

Objectives: Visual contrast detection thresholds and suprathreshold contrast discrimination thresholds were compared to luminance and flash/pattern electroretinograms (ERG) and visually evoked potentials (VEP) in patients with Parkinson's disease (n = 31), patients with multiple system atrophy (n =6), patients with progressive supranuclear palsy (n = 6) and control patients without central nervous disease (n = 33). Methods: The stimuli were luminance modulated full-field (flash) or horizontally oriented sinewave gratings (pattern), the latter having either a low(0.5 cycles/deg) or medium (4.0 cycles/deg) spatial frequency. Stimulus contrast ranged from 10 to 80% so that contrast response functions could be derived. Results: Contrast thresholds were higher in the patients with Parkinson's disease than in the control patients. Contrast discrimination thresholds were also somewhat elevated in patients with Parkinson's disease. Pattern ERGamplitudes were significantly reduced in patients with Parkinson's diseasefor the medium spatial frequency stimulus, but less for the low spatial frequency and flash stimuli. Conclusions: Our results suggest that Parkinson's disease impairs contrastprocessing in the retina. VEP amplitudes did not significantly differ between the groups for the conditions tested. Patients with progressive supranuclear palsy also showed impaired contrast perception and reduced ERG amplitudes, whereas patients with multiple system atrophy were less impaired. (C)2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:08:34