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Titolo:
Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferation
Autore:
Bischof, RJ; Zafiropoulos, D; Hamilton, JA; Campbell, IK;
Indirizzi:
Univ Melbourne, Royal Melbourne Hosp, Dept Med, Inflammatory Res Ctr, Parkville, Vic, Australia Univ Melbourne Parkville Vic Australia es Ctr, Parkville, Vic, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
fascicolo: 2, volume: 119, anno: 2000,
pagine: 361 - 367
SICI:
0009-9104(200002)119:2<361:EOAIAB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGEN-INDUCED ARTHRITIS; HUMAN SYNOVIAL FIBROBLASTS; HUMAN ARTICULAR-CARTILAGE; TUMOR-NECROSIS-FACTOR; RHEUMATOID-ARTHRITIS; GM-CSF; MICE; INTERLEUKIN-1; CHONDROCYTES; CYTOKINES;
Keywords:
rheumatoid arthritis; inflammatory mediators; cytokines; in vivo animal models; macrophages;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Bischof, RJ Univ Melbourne, Sch Vet Sci, Ctr Anim Biotechnol, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 c 3010, Australia
Citazione:
R.J. Bischof et al., "Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferation", CLIN EXP IM, 119(2), 2000, pp. 361-367

Abstract

CSF-1 and GM-CSF have been implicated in the pathogenesis of rheumatoid arthritis. We report the effects of CSF-1 and GM-CSF in the development of anacute methylated bovine serum albumin (mBSA)-induced murine arthritis model. Examination of histopathological features revealed that the systemic administration of CSF-1 or GM-CSF following mBSA administration into the knee resulted in the exacerbation of arthritis. This included synovial hyperplasia and joint inflammation, most evident at 7 and 14 days post-mBSA administration, and the appearance of erosive pannus tissue. The exacerbation by CSF-1 and GM-CSF was not sustained but declined in incidence and severity by 21 days post-mBSA administration, similar to the effects of IL-1 beta in this model, reported here and previously. Macrophages expressing Mac-2 and F4/80 were a prominent feature of the pathology observed, particularly the infiltration of Mac-2(+) macrophages seen in all mice administered CSF-1, GM-CSF or IL-1 beta. Present in inflamed knees was a locally dividing population of cells which included Mac-2(+) and F4/80(+) macrophages. These studiesdemonstrate that CSF-1 and GM-CSF can exacerbate and prolong the histopathology of acute inflammatory arthritis and lend support to monocytes/macrophages being a driving influence in the pathogenesis of inflammatory arthritis.

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Documento generato il 04/12/20 alle ore 03:45:17