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Titolo:
Michel's medium: a potential alternative to cryoprotection for tissue transport in the investigation of genetic skin disease
Autore:
Woollons, A; Holmes, GJ; Gratian, MJ; Bhogal, BS; Black, MM;
Indirizzi:
Univ London, Guys Kings Coll & St Thomas Med & Dent Sch, St Johns Inst Dermatol, Dept Dermatopathol, London WC1E 7HU, England Univ London London England WC1E 7HU matopathol, London WC1E 7HU, England
Titolo Testata:
CLINICAL AND EXPERIMENTAL DERMATOLOGY
fascicolo: 6, volume: 24, anno: 1999,
pagine: 487 - 489
SICI:
0307-6938(199911)24:6<487:MMAPAT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUNCTIONAL EPIDERMOLYSIS-BULLOSA; PEMPHIGOID ANTIGEN; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Woollons, A St Thomas Hosp, St Johns Inst Dermatol, Lambeth Palace Rd, London SE1 7EH,England St Thomas Hosp Lambeth Palace Rd London England SE1 7EH gland
Citazione:
A. Woollons et al., "Michel's medium: a potential alternative to cryoprotection for tissue transport in the investigation of genetic skin disease", CLIN EXP D, 24(6), 1999, pp. 487-489

Abstract

Michel's medium is now well established as a transport medium to maintain tissue-fixed immunoreactants prior to direct immunofluorescence and immunoelectron microscopy. This is a practical alternative to cryofixation prior to transportation when sending skin biopsies for the investigation of cutaneous immunobullous disease. In this study we have demonstrated preservation of the cutaneous basement membrane zone proteins in skin biopsies stored inMichel's medium for periods of up to 28 days - proving that Michel's medium can be used as a transport medium when sending skin biopsies for immunohistochemical studies to determine the structural and molecular deficiencies in genodermatoses such as inherited forms of epidermolysis bullosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:50:57