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Titolo:
Increased mast cell tryptase in sudden infant death - anaphylaxis, hypoxiaor artefact?
Autore:
Edston, E; Gidlund, E; Wickman, M; Ribbing, H; Van Hage-Hamsten, M;
Indirizzi:
Linkoping Univ Hosp, Dept Forens Med, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 , S-58185 Linkoping, Sweden Karolinska Inst, Dept Forens Med, Stockholm, Sweden Karolinska Inst Stockholm Sweden st, Dept Forens Med, Stockholm, Sweden Karolinska Hosp & Inst, Dept Environm Hlth, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden nvironm Hlth, Stockholm, Sweden Umea Univ, Dept Forens Med, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 niv, Dept Forens Med, S-90187 Umea, Sweden Karolinska Hosp & Inst, Dept Clin Immunol, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden Clin Immunol, Stockholm, Sweden
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 12, volume: 29, anno: 1999,
pagine: 1648 - 1654
SICI:
0954-7894(199912)29:12<1648:IMCTIS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM; LUNG; IGE;
Keywords:
anaphylaxis; complement; immunoglobulin G; mast cell; sudden infant death syndrome; tryptase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Edston, E Linkoping Univ Hosp, Dept Forens Med, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 Linkoping, Sweden
Citazione:
E. Edston et al., "Increased mast cell tryptase in sudden infant death - anaphylaxis, hypoxiaor artefact?", CLIN EXP AL, 29(12), 1999, pp. 1648-1654

Abstract

Background Increased concentrations of mast cell tryptase in post mortem blood have frequently been observed in sudden infant deaths but the cause ofthis has not yet been clarified. Objective The aim was to evaluate factors (immunological, morphological and anamnestic data) behind the observed increase in mast cell tryptase in sudden infant deaths with elevated tryptase. Methods Mast cell tryptase and total immunoglobulin (Ig) E were measured in post mortem sera from 44 infants younger than 1.5 years. Radioallergosorbent tests were performed for possible allergens (mixture for relevant food allergens, Phadiatop and latex). IgG subclasses, IgM, and complement factors (C3, C4 and factor B) were measured with radial immunodiffusion. Mast cells, labelled with antibodies against mast cell tryptase, were counted in the lungs and heart. The circumstances of death and medical history of the deceased infant and family were obtained through police and hospital records. Results In 40% of the SIDS cases tryptase was elevated (> 10 mu g/L). Total IgE in serum was increased in 33% compared with clinical reference valuesbut showed no association with mast cell tryptase. RAST tests were positive in three cases. In one of these cases both tryptase and total IgE were elevated. The only variable that was associated with high tryptase values wasprone position at death (P less than or equal to 0.05 ). Allergy or asthmain the family were alleged in 50% of the cases, but was not associated with elevated tryptase or IgE. Children with elevated total IgE also displayedhigh concentrations of IgG1 and IgG2. Infants who died in the spring had significantly higher IgE than the others (P less than or equal to 0.05). Conclusion The results do not support the hypothesis that the elevated tryptase concentrations in sudden infant death are caused by allergy. The association between prone position at death and elevated tryptase could hypothetically be explained by mast cell degranulation due to, for example, a hypoxic stimulus in these infants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:19:42