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Titolo:
Enzymatic synthesis of beta-D-glucuronides in an enzyme membrane reactor
Autore:
Pfaar, U; Gygax, D; Gertsch, W; Winkler, T; Ghisalba, O;
Indirizzi:
Novartis Pharma AG, Preclin Safety Drug Metab & Pharmacokinet, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland Univ Appl sci, Dept Chem, CH-4132 Muttenz, Switzerland Univ Appl sci Muttenz Switzerland CH-4132 , CH-4132 Muttenz, Switzerland Novartis Crop Protect AG, Spect, CH-4002 Basel, Switzerland Novartis Crop Protect AG Basel Switzerland CH-4002 02 Basel, Switzerland Novartis Pharma AG, Res Core Technol area, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
CHIMIA
fascicolo: 12, volume: 53, anno: 1999,
pagine: 590 - 593
SICI:
0009-4293(1999)53:12<590:ESOBIA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIRUBIN UDP-GLUCURONOSYLTRANSFERASE; LIVER MICROSOMAL VESICLES; HUMAN SERUM-ALBUMIN; SUBSTRATE-SPECIFICITY; CHEMICAL SYNTHESIS; ACYL GLUCURONIDES; LIQUID-CHROMATOGRAPHY; EXTRAHEPATIC TISSUES; MASS-SPECTROMETRY; PRODRUG THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Pfaar, U Novartis Pharma AG, Preclin Safety Drug Metab & Pharmacokinet, CH-4002 Basel, Switzerland Novartis Pharma AG Basel Switzerland CH-4002 Basel, Switzerland
Citazione:
U. Pfaar et al., "Enzymatic synthesis of beta-D-glucuronides in an enzyme membrane reactor", CHIMIA, 53(12), 1999, pp. 590-593

Abstract

The production of two O-glucuronides in an enzyme membrane reactor on a 100 to 200 mg scale was examined. The aglycons were conjugated with the cc-substrate beta-D-uridine diphosphoglucuronic acid (UDPGA) in the presence of a guinea-pig liver preparation. The continuous synthesis, which was run in an enzyme membrane reactor, was followed depending on the substrate up to 118 hours or 24 hours, respectively. The reaction was monitored by TLC or HPLC. The purification of the two glucuronides was carried out by ion-exchange chromatography and by reversed-phase HPLC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:30:19