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Titolo:
CXC-chemokines, a new group of cytokines in congestive heart failure - possible role of platelets and monocytes
Autore:
Damas, JK; Gullestad, L; Ueland, T; Solum, NO; Simonsen, S; Froland, SS; Aukrust, P;
Indirizzi:
Univ Oslo, Natl Hosp, Res Inst Internal Med, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Res Inst Internal Med, N-0027 Oslo, Norway Univ Oslo, Natl Hosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 atl Hosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo, Natl Hosp, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Hosp, Endocrinol Sect, N-0027 Oslo, Norway Univ Oslo, Natl Hosp, Dept Internal Med, Sect Clin Immunol & Infect Dis, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 n Immunol & Infect Dis, N-0027 Oslo, Norway
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 2, volume: 45, anno: 2000,
pagine: 428 - 436
SICI:
0008-6363(20000114)45:2<428:CANGOC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ELEVATED CIRCULATING LEVELS; FACTOR-ALPHA; IN-VIVO; CHEMOTACTIC CYTOKINES; ADHESION MOLECULES; CARDIAC MYOCYTES; HIV-INFECTION; NITRIC-OXIDE; ACTIVATION;
Keywords:
cytokines; heart failure; infection/inflammation; leukocytes; platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Aukrust, P Univ Oslo, Natl Hosp, Res Inst Internal Med, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 nternal Med, N-0027 Oslo, Norway
Citazione:
J.K. Damas et al., "CXC-chemokines, a new group of cytokines in congestive heart failure - possible role of platelets and monocytes", CARDIO RES, 45(2), 2000, pp. 428-436

Abstract

Objectives: The purpose of the present study was to examine the circulating levels of CXC-chemokines in patients with various degree of congestive heart failure (CHF). Background: CXC-chemokines may be important mediators inthe persistent immune activation observed in CHF patients by activation ofcirculating neutrophils, T-cells and monocytes and possibly by the recruitment of these cells into the failing myocardium. Methods: Levels of interleukin (IL)-8, growth-regulated oncogene (GRO)alpha and epithelial neutrophilactivating peptide (ENA)-78 were measured both in serum and in platelet-free plasma by enzyme immunoassay in 47 patients with CKF and in 20 healthy controls. Results: (i) CHF patients had significantly elevated levels of allthe three CXC-chemokines with IL-8 and GRO alpha showing a gradual increase along with increasing NYHA class. (ii) There was an inverse correlation between IL-8 and left ventricular ejection fraction (EF) and cardiac index (CI). (iii) Both unstimulated and lipopolysaccharide (LPS)-stimulated monocytes from CHF patients released markedly elevated amounts of all three CXC-chemokines. (iv) Platelets from patients with severe CHF were characterised by decreased content of GRO alpha( and ENA-78 as well as decreased release of these chemokines upon thrombin receptor stimulation. (v) Activated platelets stimulated peripheral blood mononuclear cells in vitro to enhanced release of IL-8, and neutralising antibodies against ENA-78 inhibited this interaction. Conclusions: This study demonstrates for the first time elevated levels of CXC-chemokines in CHF, which may be of importance for progressionof heart failure. Our findings further suggest that activated monocytes and platelets may contribute to enhanced CXC-chemokine levels in CHF. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:16:33