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Titolo:
IMMUNOHISTOCHEMICAL DESCRIPTION OF NITRIC-OXIDE SYNTHASE ISOFORMS IN HUMAN CLITORIS
Autore:
BURNETT AL; CALVIN DC; SILVER RI; PEPPAS DS; DOCIMO SG;
Indirizzi:
JOHNS HOPKINS UNIV HOSP,JAMES BUCHANAN BRADY UROL INST,DEPT UROL,DIV PEDIAT UROL,MARBURG 407 BALTIMORE MD 21287 JOHNS HOPKINS UNIV HOSP,JAMES BUCHANAN BRADY UROL INST,DIV ADULT UROLBALTIMORE MD 21287 JOHNS HOPKINS UNIV HOSP,SCH MED BALTIMORE MD 21287 WALTER REED ARMY MED CTR,DEPT UROL WASHINGTON DC 20307
Titolo Testata:
The Journal of urology
fascicolo: 1, volume: 158, anno: 1997,
pagine: 75 - 78
SICI:
0022-5347(1997)158:1<75:IDONSI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAVERNOSUM SMOOTH-MUSCLE; CYCLIC-GMP FORMATION; CORPUS CAVERNOSUM; NERVE-FIBERS; RELAXATION; PHYSIOLOGY; ERECTION; NEUROTRANSMISSION; INNERVATION; MEDIATOR;
Keywords:
NITRIC OXIDE; CLITORIS; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A.L. Burnett et al., "IMMUNOHISTOCHEMICAL DESCRIPTION OF NITRIC-OXIDE SYNTHASE ISOFORMS IN HUMAN CLITORIS", The Journal of urology, 158(1), 1997, pp. 75-78

Abstract

Purpose: Our aim was to identify and localize nitric oxide synthase isoforms in the human clitoris in support of the hypothesis that nitricoxide mediates erectile function in this organ. Materials and Methods: Nitric oxide synthase immunohistochemistry studies specific for neuronal, inducible and endothelial isoforms of the enzyme were performed on human clitoral tissue obtained from 4 patients (3 with female pseudohermaphroditism and 1 with true hermaphroditism) at feminizing genitoplasty and from I phenotypically normal woman at autopsy. Results: Neuronal nitric oxide synthase immunoreactivity was detected in nerve bundles and fibers coursing within the glans clitoris and corpora cavernosa of the clitoris, predominating in the latter tissue. Specific inducible nitric oxide synthase immunoreactivity was not identified. Endothelial nitric oxide synthase immunoreactivity was detected in vascular and sinusoidal endothelium of these tissues with a predominance in theglans clitoris. Conclusions: The presence and anatomical localizations of nitric oxide synthase isoforms in the human clitoris indicate that nitric oxide is generated in this organ. These data suggest that nitric oxide may be involved in the erectile physiology of the clitoris as a modulator of clitoral smooth muscle activity. Functional studies are required to support this hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:18:52