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Titolo:
Central adenosine A(2A) receptors: an overview
Autore:
Moreau, JL; Huber, G;
Indirizzi:
F Hoffmann La Roche & Co Ltd, Preclin CNS Res, Div Pharma, PRPN, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4070 asel, Switzerland
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 1, volume: 31, anno: 1999,
pagine: 65 - 82
SICI:
0165-0173(199912)31:1<65:CAARAO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ELECTRICAL BRAIN-STIMULATION; PHEOCHROMOCYTOMA PC12 CELLS; MORPHINE-INDUCED ANALGESIA; MESSENGER-RNA EXPRESSION; 3RD INTRACELLULAR LOOP; RAT CEREBRAL-CORTEX; AMINO-ACID RELEASE; C-FOS EXPRESSION; ACETYLCHOLINE-RELEASE;
Keywords:
adenosine; A(2A) receptor; behavioural function; neuropsychiatric disorder;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
194
Recensione:
Indirizzi per estratti:
Indirizzo: Moreau, JL F Hoffmann La Roche & Co Ltd, Preclin CNS Res, Div Pharma, PRPN, 72-141, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd 72-141 Basel Switzerland CH-4070
Citazione:
J.L. Moreau e G. Huber, "Central adenosine A(2A) receptors: an overview", BRAIN RES R, 31(1), 1999, pp. 65-82

Abstract

Recent advances in molecular biology, biochemistry, cell biology and behavioral pharmacology together with the development of more selective ligands to the various adenosine receptors have increased our understanding of the functioning of central adenosine A(2A) receptors. The A(2A) receptor is oneof four adenosine receptors found in the brain. Its expression is highest in striatum, nucleus accumbens and olfactory tubercles, although it also occurs in neurons and microglia in most other brain regions. The receptor hasseven transmembrane domains and couples via Gs to adenyl cyclase stimulation. Antagonistic interactions between A(2A) receptors and dopamine D-2 receptors have been described, as stimulation of the A(2A) receptor leads to a reduction in the affinity of D-2 receptors for D-2 receptor agonists, The A(2A) receptor is thought to play a role in a number of physiological responses and pathological conditions. Indeed, A(2A) receptor antagonists may be useful for the treatment of acute and chronic neurodegenerative disorders such as cerebral ischemia or Parkinson's disease. A(2A) receptor agonists may treat certain types of seizures or sleep disorders. This review discussesthe characteristics, distribution, pharmacochemical properties and regulation of central A(2A) receptors, as well as A(2A) receptor-mediated behavioural responses and their potential role in various neuropsychiatric disorders. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:34:09