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Titolo:
Increased adrenocorticotropin responses to acute stress in Otsuka Long-Evans Tokushima Fatty (type 2 diabetic) rats
Autore:
Takao, T; Tojo, C; Nishioka, T; Hashimoto, K;
Indirizzi:
Kochi Med Sch, Dept Internal Med 2, Nanko Ku, Kochi 7838505, Japan Kochi Med Sch Kochi Japan 7838505 Med 2, Nanko Ku, Kochi 7838505, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 852, anno: 2000,
pagine: 110 - 115
SICI:
0006-8993(20000103)852:1<110:IARTAS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PITUITARY-ADRENAL AXIS; FACTOR RECEPTORS; ACTH RELEASE; VASOPRESSIN; MELLITUS; HORMONE; HYPERCORTISOLISM; SECRETION; FEEDBACK;
Keywords:
adrenocorticotropic hormone; corticotropin-releasing factor; corticosterone; diabetes mellitus; Otsuka Long-Evans Tokushima Fatty rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Takao, T Kochi Med Sch, Dept Internal Med 2, Nanko Ku, Okoh Cho, Kochi 7838505, Japan Kochi Med Sch Okoh Cho Kochi Japan 7838505 Kochi 7838505, Japan
Citazione:
T. Takao et al., "Increased adrenocorticotropin responses to acute stress in Otsuka Long-Evans Tokushima Fatty (type 2 diabetic) rats", BRAIN RES, 852(1), 2000, pp. 110-115

Abstract

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new diabetic strainof mts whose disease closely resembles human type 2 diabetes. We measured plasma adrenocorticotropic hormone (ACTH) and corticostrone Levels, and iodine-125-labeled ovine corticotropin-releasing factor ([I-125]oCRF) binding in the anterior pituitary after ether-laparotomy stress in OLETF rats to examine the alteration of the hypothalamic-pituitary-adrenal (HPA) axis. In addition, we examined ACTH secretion following CRF administration in vivo and in vitro to characterize the mechanisms regulating the IBA axis in OLETF rats. Body weight, plasma glucose and insulin levels in OLETF rats were significantly higher than that in Long-Evans Tokushima Otsuka (LETO) rats. Basal plasma ACTH levels tended to be higher in OLETF rats than in LETO but itdid not reach statistical significance. Ether-laparotomy stress dramatically increased plasma ACTH levels at 2 h after the stress both in either OLETF and LETO rats; the peak plasma ACTH level in OLETF rats following the stress was significantly greater than in LETO rats. Plasma ACTH levels following CRF (2 mu g/kg, i.v.) in OLETF and LETO rats showed statistically significant increases at 10 and 30 min after CRF administration compared to ACTH levels at 0 min, however, the peak plasma ACTH level in OLETF rats at 10 min after CRF administration was significantly greater than in LETO rats. In contrast to ACTH levels, no significant differences in corticosterone levels between OLETF and LETO were observed at any of the time points. CRF (10 ng/ml) significantly increased ACTH secretion in pituitary cultures from OLETF compared to LETO rats. These data reveal a complex regulation of the endocrine system in this diabetic condition and suggest that HPA axis may be more stimulated during acute stress in diabetes mellitus than in unaffected subjects. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 16:24:36