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Titolo:
Synthesis and monoamine oxidase B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines
Autore:
Yu, JA; Castagnoli, N;
Indirizzi:
Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA Virginia Polytech Inst & State Univ Blacksburg VA USA 24061 VA 24061 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 12, volume: 7, anno: 1999,
pagine: 2835 - 2842
SICI:
0968-0896(199912)7:12<2835:SAMOBS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-INDUCED NEUROTOXICITY; BIOLOGICAL-ACTIVITY; INDUCED PARKINSONISM; CATALYZED OXIDATION; MPTP ANALOGS; AMINE; DERIVATIVES; METABOLISM; INHIBITION; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Castagnoli, N Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA Virginia Polytech Inst & State Univ Blacksburg VA USA 24061
Citazione:
J.A. Yu e N. Castagnoli, "Synthesis and monoamine oxidase B substrate properties of 1-methyl-4-heteroaryl-1,2,3,6-tetrahydropyridines", BIO MED CH, 7(12), 1999, pp. 2835-2842

Abstract

Six analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP, (1)] bearing various heteroaryl groups at C-4 were synthesized and examined for their monoamine oxidase B substrate properties. The C-4 substituents include the 1-ethylpyrrol-2-yl, 1-propylpyrrol-2-yl, 1-isopropylpyrrol-2-yl, 1-cyclopropylpyrrol-2-yl, 3-ethylfuran-2-yI and 3-ethylthien-2-yl groups. The results provide information concerning steric and polar interactions betweenthe C-4 substituent and the active site of MAO-B that are transmitted to the position of oxidation at C-6 of the tetrahydropyridinyl moiety. (C) 1999Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/08/20 alle ore 14:33:25