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Titolo:
Enantiomer-specific high-performance liquid chromatography with fluorescence detection of methamphetamines in abusers' hair and urine
Autore:
Al-Dirbashi, O; Wada, M; Kuroda, M; Inuduka, S; Nakashima, K;
Indirizzi:
Nagasaki Univ, Sch Pharmaceut Sci, Nagasaki 8528521, Japan Nagasaki Univ Nagasaki Japan 8528521 maceut Sci, Nagasaki 8528521, Japan Kinki Reg Narcot Control Off, Chuo Ku, Osaka, Japan Kinki Reg Narcot Control Off Osaka Japan rol Off, Chuo Ku, Osaka, Japan
Titolo Testata:
BIOMEDICAL CHROMATOGRAPHY
fascicolo: 8, volume: 13, anno: 1999,
pagine: 543 - 547
SICI:
0269-3879(199912)13:8<543:EHLCWF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPTICAL ISOMERS; CAPILLARY ELECTROPHORESIS; BETA-CYCLODEXTRIN; CHIRAL SEPARATION; RAT URINE; AMPHETAMINE; METABOLITES; HPLC; DERIVATIVES; CHLORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Nakashima, K Nagasaki Univ, Sch Pharmaceut Sci, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan Nagasaki Univ 1-14 Bunkyo Machi Nagasaki Japan 8528521 Japan
Citazione:
O. Al-Dirbashi et al., "Enantiomer-specific high-performance liquid chromatography with fluorescence detection of methamphetamines in abusers' hair and urine", BIOMED CHRO, 13(8), 1999, pp. 543-547

Abstract

Enantiomer-specific high-performance liquid chromatography with fluorescence detection using 4-(4,5-diphenyl-1H-imidazol-2-yl)-benzoyl chloride as a fluorescence labeling reagent was applied to determine methamphetamine and its metabolites in abusers' hair and urine. Hair samples were segmentally analyzed based on 1 cm long segments. In four hair samples, only the S(+)-enantiomers of methamphetamine and its N-demethylated metabolite, S(+)-amphetamine were detected. Satisfactory correlation (r = 0.901) between the results of high-performance liquid chromatography-fluorescence and those of gas chromatography-nitrogen phosphorous detection was obtained (n = 19). In an abuser's urine sample, the S(+)- and R(-)-enantiomers of methamphetamine, amphetamine and para-hydroxymethamphetamine were detected. The degree of N-demethylation of S(+)-methamphetamine into the corresponding metabolite of amphetamine was significantly higher than that of the R(-)-enantiomer. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:33:19