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Titolo:
Decreased dendritic spine density on prefrontal cortical pyramidal neuronsin schizophrenia
Autore:
Glantz, LA; Lewis, DA;
Indirizzi:
Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 eurosci, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 1, volume: 57, anno: 2000,
pagine: 65 - 73
SICI:
0003-990X(200001)57:1<65:DDSDOP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; GRAY-MATTER VOLUME; MEDIODORSAL THALAMIC NUCLEUS; CEREBRAL BLOOD-FLOW; AXON TERMINALS; VISUAL-CORTEX; ALZHEIMERS-DISEASE; RHESUS-MONKEYS; WORKING-MEMORY; FRONTAL LOBES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, DA Univ Pittsburgh, Dept Neurosci, 3811 OHara St,W1650 Biomed Sci Tower, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St,W1650 Biomed Sci Tower Pittsburgh PA USA 15213
Citazione:
L.A. Glantz e D.A. Lewis, "Decreased dendritic spine density on prefrontal cortical pyramidal neuronsin schizophrenia", ARCH G PSYC, 57(1), 2000, pp. 65-73

Abstract

Background: The pathophysiological characteristics of schizophrenia appearto involve altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that layer 3 pyramidal neurons play in corticocortical and thalamocortical connectivity, we hypothesized that the excitatory inputs to these neurons are altered in subjects with schizophrenia. Methods: To test this hypothesis, we determined the density of dendritic spines, markers of excitatory inputs, on the basilar dendrites of Golgi-impregnated pyramidal neurons in the superficial and deep portions of layer 3 in the dorsolateral prefrontal cortex (area 46) and in layer 3 of the primary visual cortex (area 17) of 15 schizophrenic subjects, 15 normal control subjects, and 15 nonschizophrenic subjects with a psychiatric illness (referred to as psychiatric subjects). Results: There was a significant effect of diagnosis on spine density onlyfor deep layer 3 pyramidal neurons in area 46 (P = .006). In the schizophrenic subjects, spine density on these neurons was decreased by 23% and 16% compared with the normal control (P = .004) and psychiatric (P = .08) subjects, respectively. In contrast, spine density on neurons in superficial layer 3 in area 46 (P = .09) or in area 17 (P = .08) did not significantly differ across the 3 subject groups. Furthermore, spine density on deep layer 3neurons in area 46 did not significantly (P = .81) differ between psychiatric subjects treated with antipsychotic agents and normal controls. Conclusion: This region- and disease-specific decrease in dendritic spine density on dorsolateral prefrontal cortex layer 3 pyramidal cells is consistent with the hypothesis that the number of cortical and/or thalamic excitatory inputs to these neurons is altered in subjects with schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 23:35:51