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Titolo:
Effects of temporal variability on P50 and the gating ratio in schizophrenia - A frequency domain adaptive filter single-trial analysis
Autore:
Patterson, JV; Jin, Y; Gierczak, M; Hetrick, WP; Potkin, S; Bunney, WE; Sandman, CA;
Indirizzi:
Univ Calif Irvine, Dept Neurol, Irvine, CA USA Univ Calif Irvine Irvine CA USA alif Irvine, Dept Neurol, Irvine, CA USA Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA USA Univ Calif Irvine Irvine CA USA t Psychiat & Human Behav, Irvine, CA USA MIG Syst Engn, Costa Mesa, CA USA MIG Syst Engn Costa Mesa CA USAMIG Syst Engn, Costa Mesa, CA USA Indiana Univ, Dept Psychol, Bloomington, IN USA Indiana Univ Bloomington IN USA Univ, Dept Psychol, Bloomington, IN USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 1, volume: 57, anno: 2000,
pagine: 57 - 64
SICI:
0003-990X(200001)57:1<57:EOTVOP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; AUDITORY EVOKED-POTENTIALS; 40 HZ-EEG; NEUROPHYSIOLOGICAL EVIDENCE; PSYCHIATRIC-INPATIENTS; LATENCY VARIABILITY; ANIMAL-MODEL; P3; SUPPRESSION; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Patterson, JV Fairview Dev Ctr, 2501 Harbor Blvd,Box 5A, Costa Mesa, CA USA Fairview Dev Ctr 2501 Harbor Blvd,Box 5A Costa Mesa CA USA
Citazione:
J.V. Patterson et al., "Effects of temporal variability on P50 and the gating ratio in schizophrenia - A frequency domain adaptive filter single-trial analysis", ARCH G PSYC, 57(1), 2000, pp. 57-64

Abstract

Background: Deficits in attention and cognition are common in schizophrenia. Using an auditory dual-click paradigm, a number of studies have found that, compared with normal controls, patients with schizophrenia show impaired inhibition, or gating, of repeated stimulation as measured by the averageP50 evoked response to the second click. Since responses to many trials are collected to study the average response, fluctuations in the timing of the P50 response from trial to trial may influence the differences observed. We present a computerized, objective procedure that evaluates temporal variability in brain responses of patients with schizophrenia. Methods: Ten normal controls and 10 patients diagnosed with schizophrenia were studied using the dual-click procedure. For each single trial, the temporal shift in P50 that yielded the best alignment with the average P50 response was used to derive a measure of P50 temporal variability from trial to trial and to form P50 averages corrected for temporal variability. Results: Patients with schizophrenia had significantly more temporal variability than normal controls. Correction for temporal variability in the P50responses increased the size of P50 for both patients with schizophrenia and normal controls. Patients with schizophrenia had smaller P50 responses to the first click than controls and less inhibition to the second click before, but not after, correction for temporal variability. Conclusions: These findings suggest that temporal variability contributes significantly to the P50 response as measured using the gating procedure. The measure of temporal variability may provide a new index of inhibitory and attentional function in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:55:48