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Titolo:
Interleukin-10 in cutaneous disorders: implications for its pathophysiological importance and therapeutic use
Autore:
Asadullah, K; Sabat, R; Wiese, A; Docke, WD; Volk, HD; Sterry, W;
Indirizzi:
Schering AG, Dept Expt Dermatol, D-13342 Berlin, Germany Schering AG Berlin Germany D-13342 xpt Dermatol, D-13342 Berlin, Germany Humboldt Univ, Dept Dermatol, Charite, Berlin, Germany Humboldt Univ Berlin Germany v, Dept Dermatol, Charite, Berlin, Germany Humboldt Univ, Dept Med Immunol, Charite, Berlin, Germany Humboldt Univ Berlin Germany Dept Med Immunol, Charite, Berlin, Germany
Titolo Testata:
ARCHIVES OF DERMATOLOGICAL RESEARCH
fascicolo: 12, volume: 291, anno: 1999,
pagine: 628 - 636
SICI:
0340-3696(199912)291:12<628:IICDIF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; T-CELL LYMPHOMA; SYSTEMIC LUPUS-ERYTHEMATOSUS; PERIPHERAL-BLOOD EOSINOPHILS; INHIBITS CYTOKINE PRODUCTION; NORMAL HUMAN KERATINOCYTES; NECROSIS-FACTOR-ALPHA; HUMAN EPIDERMAL-CELLS; VIRUS PROTEIN BCRF1; INTERFERON-GAMMA;
Keywords:
dermatology IL-10; cytokines; inflammation; psoriasis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Asadullah, K Schering AG, Dept Expt Dermatol, D-13342 Berlin, Germany Schering AG Berlin Germany D-13342 D-13342 Berlin, Germany
Citazione:
K. Asadullah et al., "Interleukin-10 in cutaneous disorders: implications for its pathophysiological importance and therapeutic use", ARCH DERM R, 291(12), 1999, pp. 628-636

Abstract

With its antiinflammatory and immunosuppressive properties interleukin-10 (IL-10) plays a dominant role in several immune reactions including regulatory mechanisms in the skin. The overexpression of this mediator has been reported in some inflammatory dermatoses as well as in various skin tumors. These observations are of importance since they may explain the limitation of hyperinflammatory conditions as in eczemas and erythemas on the one hand and the suppression of an adequate antitumor response and thereby the progression of malignant tumors on the other hand. Moreover, elevated IL-10 expression might contribute to an enhanced risk of development of microbacterial superinfections, a frequent finding in several dermatoses, and might alsobe involved in the pathogenesis of connective tissue diseases. In contrast, recent studies indicate a relative IL-10 deficiency in psoriasis, Early clinical data from psoriatic patients treated with recombinant human IL-10 suggest the therapeutic potential of this cytokine and underline its impact on the regulation of the skin immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 14:16:01