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Titolo:
Small amount of low-residue diet with parenteral nutrition can prevent decreases in intestinal mucosal integrity
Autore:
Omura, K; Hirano, K; Kanehira, E; Kaito, K; Tamura, M; Nishida, S; Kawakami, K; Watanabe, Y;
Indirizzi:
Kanazawa Univ, Sch Med, Fac Med, Dept Surg 1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan
Titolo Testata:
ANNALS OF SURGERY
fascicolo: 1, volume: 231, anno: 2000,
pagine: 112 - 118
SICI:
0003-4932(200001)231:1<112:SAOLDW>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BACTERIAL TRANSLOCATION; ELEMENTAL DIET; PROTEIN-MALNUTRITION; BARRIER FUNCTION; GUT; IMMUNITY; ENDOTOXIN; PERMEABILITY; ACTIVATION; FIBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Omura, K Kanazawa Univ, Sch Med, Fac Med, Dept Surg 1, Takaramachi 13-1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Takaramachi 13-1 Kanazawa Ishikawa Japan 9208641 an
Citazione:
K. Omura et al., "Small amount of low-residue diet with parenteral nutrition can prevent decreases in intestinal mucosal integrity", ANN SURG, 231(1), 2000, pp. 112-118

Abstract

ObjectiveTo investigate the suitable combination ratio of low-residue diet (LRD) and parenteral nutrition (PN) for nutritional support of surgical patients. Summary Background DataBacterial translocation (BT) is a severe complication of total parenteral nutrition (TPN). However, it is sometimes impossible to supply sufficient amounts of nutrients to surgical patients by the enteral route. The authors reported previously that concomitant use of LRD with PN provided preferablenutritional support for patients undergoing surgery for colorectal cancer. MethodsNinety male Donryu rats were used for three experiments. In experiment 1, rats were divided into two groups to receive TPN or total enteral nutritionwith LRD. In experiment 2, rats were divided into six groups, receiving variable amounts of LRD, In experiment 3, rats were divided into five groups to receive isocaloric nutritional support with variable proportions of PN and LRD. Intestinal permeability was assessed by monitoring urinary excretion of phenolsulfonphthalein. BT was assessed in tissue cultures of mesenteric lymph nodes and spleen. ResultsIn experiment 1, increases in intestinal permeability and BT were observedin rats maintained on 7-day TPN, but not in those maintained on total enteral nutrition for up to 14 days, In experiment 2, the changes in body weight of rats were correlated with the dose of LRD. However, the intestinal permeability was increased only in rats receiving LRD at 15 kcal/kg per day. In experiment 3, additive LRD corresponding to 15% of total caloric intake prevented increases in intestinal permeability and BT. ConclusionCombined nutritional therapy consisting of PN and small amounts of LRD canprovide better nutritional support than TPN for surgical patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 06:47:24