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Titolo:
Candesartan cilexetil: An angiotensin II receptor blocker
Autore:
Stoukides, CA; McVoy, HJ; Kaul, AF;
Indirizzi:
Med Outcomes Management Inc, Foxborough, MA 02035 USA Med Outcomes Management Inc Foxborough MA USA 02035 borough, MA 02035 USA Univ Rhode Isl, Coll Pharm, Kingston, RI 02881 USA Univ Rhode Isl Kingston RI USA 02881 , Coll Pharm, Kingston, RI 02881 USA
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 12, volume: 33, anno: 1999,
pagine: 1287 - 1298
SICI:
1060-0280(199912)33:12<1287:CCAAIR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; SMOOTH-MUSCLE CELLS; ESSENTIAL-HYPERTENSION; VASCULAR BED; ANTAGONIST; TCV-116; LOSARTAN; CV-11974; RATS; PHARMACOKINETICS;
Keywords:
candesartan cilexetil; angiotensin II receptor blocker; congestive heart failure; hypertension;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Kaul, AF Med Outcomes Management Inc, 132 Cent St,Ste 106, Foxborough, MA 02035 USA Med Outcomes Management Inc 132 Cent St,Ste 106 Foxborough MA USA02035
Citazione:
C.A. Stoukides et al., "Candesartan cilexetil: An angiotensin II receptor blocker", ANN PHARMAC, 33(12), 1999, pp. 1287-1298

Abstract

OBJECTIVE: To summarize and critique the medical literature on candesartancilexetil, an angiotensin II receptor blocker (ARB). DATA SOURCES: MEDLINE searches (January 1966-January 1999) and manufacturer prescribing literature were used to identify articles on candesartan cilexetil. Bibliographies were also reviewed for germane articles. STUDY SELECTION: Study and review articles describing the chemistry, humanpharmacology, pharmacodynamics, pharmacokinetics, placebo-controlled trials, comparative trials, and clinical application of candesartan cilexetil based on the published literature and premarketing clinical trials were reviewed. DATA EXTRACTION: All literature on the use of candesartan cilexetil for treating hypertension and congestive heart failure were included. DATA SYNTHESIS: ARBs are a new class of drugs with increasing use in treating hypertension. Studies are ongoing to determine the role of these agentsin preventing remodeling after myocardial infarction and in patients with congestive heart failure. Candesartan cilexetil is among the newest drugs in the class that includes losartan, irbesartan, and valsartan. Candesartan cilexetil has more than 1000 times more affinity for the angiotensin II, type AT(1) receptor ARBs, and the binding affinity and competitive angiotensin II receptor antagonism is stronger than that of losartan. Clinical studies in patients with hypertension have demonstrated that candesartan cilexetil, in doses of 4-16 mg, is more effective in reducing sitting diastolic blood pressure than are placebo and losartan 50 mg. Candesartan cilexetil has demonstrated reductions in blood pressure comparable to those of enalapril,with the rate of adverse events greater in the enalapril group. Dosage adjustments are not necessary in elderly patients or in patients with mild hepatic or renal dysfunction. In diabetic patients, blood glucose, hemoglobin(A1c), and serum lipids are not affected. The clinical studies demonstrated that the adverse effect profile of candesartan cilexetil was similar to that of placebo and there were no dose-dependent adverse effects. CONCLUSIONS: Candesartan cilexetil provides an alternative antihypertensive therapy that is well tolerated and effective in reducing blood pressure in a wide range of patients. Due to its greater binding affinity to the angiotensin II receptor, candesartan cilexetil appears to have a longer antihypertensive effect than losartan. This may be advantageous in decreasing morbidity and mortality associated with hypertension, although further studies are required to validate this potential advantage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:59:30