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Titolo:
Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging
Autore:
Alsop, DC; Detre, JA; Grossman, M;
Indirizzi:
Univ Penn, Med Ctr, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Radiol, Philadelphia, PA 19104 USA Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Neurol, Philadelphia, PA 19104 USA
Titolo Testata:
ANNALS OF NEUROLOGY
fascicolo: 1, volume: 47, anno: 2000,
pagine: 93 - 100
SICI:
0364-5134(200001)47:1<93:AOCBFI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ARTERIAL WATER; PERFUSION; DEMENTIA; MR; VOLUME; INVERSION; HYPOMETABOLISM; METABOLISM; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Alsop, DC Univ Penn, Med Ctr, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA Univ Penn 3400 Spruce St Philadelphia PA USA 19104 PA 19104 USA
Citazione:
D.C. Alsop et al., "Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging", ANN NEUROL, 47(1), 2000, pp. 93-100

Abstract

To evaluate the utility of arterial spin-labeled blood now magnetic resonance imaging for the detection of cerebral blood flow abnormalities in Alzheimer's disease, arterial spin-labeled blood flow images in 16 contiguous 5-mm axial sections were acquired in 18 patients diagnosed with probable Alzheimer's disease and 11 age-matched controls. Blood flow images from all subjects were transformed to a standard anatomical space for voxel-by-voxel statistical analysis. High quality blood flow images were obtained from all but 1 subject Statistical analysis demonstrated significant flow decreases relative to control subjects in temporal, parietal, frontal, and posterior cingulate cortices. Increased severity of disease, as measured by Mini-Mental State Examination, correlated with posterior parietal and posterior cingulate decreases bur not temporal decreases. Arterial spin-labeled magnetic resonance imaging was found to be an effective tool for characterizing flow decreases accompanying Alzheimer's disease. The absence of ionizing radiation or injection and the ability to obtain high quality anatomical images within the same scanning session make arterial spin labeling an attractive technique for the study of Alzheimer's disease, for the evaluation of pharmacological therapies, and, possibly, for early diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 08:59:01