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Titolo:
Propofol enhances a d-tubocurarine-induced twitch depression in septic ratdiaphragm
Autore:
Nakayama, Y; Narimatsu, E; Sumita, S; Fujimura, N; Satoh, K; Iwasaki, H; Namiki, A;
Indirizzi:
Sapporo Med Univ, Sch Med, Dept Anesthesiol, Chuo Ku, Sapporo, Hokkaido 0608543, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608543 , Hokkaido 0608543, Japan
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 1, volume: 90, anno: 2000,
pagine: 80 - 84
SICI:
0003-2999(200001)90:1<80:PEADTD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROCNEMIUS-MUSCLE; SEPSIS; CONTRACTILITY; INJURY; ENDOTOXIN; SHOCK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nakayama, Y Sapporo Med Univ, Sch Med, Dept Anesthesiol, Chuo Ku, South 1,West 16, Sapporo, Hokkaido 0608543, Japan Sapporo Med Univ South 1,West 16 Sapporo Hokkaido Japan 0608543
Citazione:
Y. Nakayama et al., "Propofol enhances a d-tubocurarine-induced twitch depression in septic ratdiaphragm", ANESTH ANAL, 90(1), 2000, pp. 80-84

Abstract

We estimated the effect of d-tubocurarine (dTc) on neuromuscular transmission and the action of propofol on dTc-induced twitch depression by using sham control and septic rat nerve-hemidiaphragm preparations in vitro. Isometric twitch tension elicited by indirect (phrenic nerve) or direct (muscle) stimulation at 0.1 Hz was evaluated. Sepsis induced by panperitonitis attenuated the twitch tension elicited by indirect and direct stimulation (P < 0.01 in each group) in the absence of significant morphological inflammatorydamage to the diaphragm. dTc (1 mu M) decreased the twitch tension elicited by indirect stimulation (P < 0.01) less intensely in the septic group than in the sham group (P < 0.01). Propofol accentuated dTc-induced depressed twitch more intensely in the septic group (P < 0.01 or 0.05). These resultsdemonstrate that sepsis attenuates both muscle contractile force and the effect of a neuromuscular blocker and that propofol more intensely enhances dTc-induced twitch depression during sepsis. Implications: Propofol and nondepolarizing muscle relaxants are widely used for various clinical cases, including sepsis. Interactions between nondepolarizing muscle relaxants and propofol during sepsis are interesting from a clinical point of view. We demonstrated that propofol significantly enhances d-tubocurarine-induced twitch depression in vitro in the septic rat model compared with that in the nonseptic rat model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:17:34