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Titolo:
Hippocampal volume reduction in major depression
Autore:
Bremner, JD; Narayan, M; Anderson, ER; Staib, LH; Miller, HL; Charney, DS;
Indirizzi:
Vet Adm Connecticut Healthcare Syst 115A, W Haven, CT 06516 USA Vet Adm Connecticut Healthcare Syst 115A W Haven CT USA 06516 T 06516 USA Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Diagnost Radiol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 , Dept Psychiat, New Haven, CT 06510 USA Natl Ctr PTSD, W Haven, CT USA Natl Ctr PTSD W Haven CT USANatl Ctr PTSD, W Haven, CT USA Yale Psychiat Inst, New Haven, CT USA Yale Psychiat Inst New Haven CT USA ale Psychiat Inst, New Haven, CT USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 1, volume: 157, anno: 2000,
pagine: 115 - 117
SICI:
0002-953X(200001)157:1<115:HVRIMD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFECTIVE-DISORDER; MEMORY IMPAIRMENT; BIPOLAR DISORDER; ABNORMALITIES; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Bremner, JD Vet Adm Connecticut Healthcare Syst 115A, 950 Campbell Ave, W Haven, CT 06516 USA Vet Adm Connecticut Healthcare Syst 115A 950 Campbell Ave W Haven CT USA 06516
Citazione:
J.D. Bremner et al., "Hippocampal volume reduction in major depression", AM J PSYCHI, 157(1), 2000, pp. 115-117

Abstract

Objective: Elevated levels of glucocorticoids in depression have been hypothesized to be associated with damage to the hippocampus, a brain area involved in learning and memory. The purpose of this study was to measure hippocampal volume in patients with depression. Method: Magnetic resonance imaging was used to measure the volume of the hippocampus in 16 patients with major depression in remission and 16 case-matched nondepressed comparison subjects. Results: Patients with depression had a statistically significant 19% smaller left hippocampal volume than comparison subjects, without smallervolumes of comparison regions (amygdala, caudate, frontal lobe, and temporal lobe) or whole brain volume. The findings were significant after brain size, alcohol exposure, age, and education were controlled for. Conclusions:These findings are consistent with smaller left hippocampal volume in depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:21:03