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Titolo:
Anomalous asymmetry of fusiform and parahippocampal gyrus gray matter in schizophrenia: A postmortem study
Autore:
McDonald, B; Highley, JR; Walker, MA; Herron, BM; Cooper, SJ; Esiri, MM; Crow, TJ;
Indirizzi:
Radcliffe Infirm, Schizophrenia Res Grp, Dept Neuropathol, Oxford OX2 6HE,England Radcliffe Infirm Oxford England OX2 6HE ropathol, Oxford OX2 6HE,England Royal Hosp Trust, Reg Neuropathol Lab, Belfast, Antrim, North Ireland Royal Hosp Trust Belfast Antrim North Ireland ast, Antrim, North Ireland Queens Univ Belfast, Dept Mental Hlth, Belfast BT7 1NN, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT7 1NN m, North Ireland Univ Headington, Prince Wales Int Ctr, Dept Psychiat, Warneford Hosp, Headington, England Univ Headington Headington England Warneford Hosp, Headington, England
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 1, volume: 157, anno: 2000,
pagine: 40 - 47
SICI:
0002-953X(200001)157:1<40:AAOFAP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; SYLVIAN FISSURE ASYMMETRY; MAGNETIC-RESONANCE; PLANUM TEMPORALE; CEREBRAL ASYMMETRY; QUANTITATIVE POSTMORTEM; AFFECTIVE-DISORDER; VENTRICULAR SIZE; BRAIN; VOLUME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Crow, TJ Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX iat, Oxford OX3 7JX, England
Citazione:
B. McDonald et al., "Anomalous asymmetry of fusiform and parahippocampal gyrus gray matter in schizophrenia: A postmortem study", AM J PSYCHI, 157(1), 2000, pp. 40-47

Abstract

Objective: Anomalies of structure and asymmetry of the parahippocampal gyrus (origin of the perforant path input to the hippocampal formation in the medial temporal lobe) have been shown in some postmortem studies of schizophrenia, but previous studies have not included the fusiform gyrus (which may have a role in facial recognition and naming), adjacent to the parahippocampal gyrus on the ventral occipitotemporal surface. Method: The volumes ofgray matter in the left and right parahippocampal and fusiform gyri were assessed with a stereological point-counting technique in the temporal robesfrom formalin-fixed brains of 27 comparison subjects and 31 patients with schizophrenia. Age was a covariate and gender was a factor in the analysis. Results: In relation to the comparison subjects, the schizophrenic patients (both sexes) had lower volumes of both the parahippocampal and fusiform gyri on the left side. For both structures a left-greater-than-right volume asymmetry was present in the comparison subjects, but this asymmetry was reversed in the parahippocampal and fusiform gyri of the schizophrenic patients. A sex difference was present with respect to age at onset-degree of anomaly of asymmetry for both gyri increased with age at onset in men but not in women. Conclusions: The findings add substance to the view that the sex-related dimension of symmetry/asymmetry is integral to the disease process in schizophrenia and draw attention to the fusiform gyrus as a structure ofparticular interest in relation to disturbances of identification and naming in psychosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:01:58