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Titolo:
Disturbed gyrification of the prefrontal region in male schizophrenic patients: A morphometric postmortem study
Autore:
Vogeley, K; Schneider-Axmann, T; Pfeiffer, U; Tepest, R; Bayer, TA; Bogerts, B; Honer, WG; Falkai, P;
Indirizzi:
Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 onn, Dept Psychiat, D-53105 Bonn, Germany
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 1, volume: 157, anno: 2000,
pagine: 34 - 39
SICI:
0002-953X(200001)157:1<34:DGOTPR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLANUM TEMPORALE ASYMMETRY; GRAY-MATTER VOLUME; STRUCTURAL ABNORMALITIES; BRAIN ABNORMALITIES; CEREBRAL-CORTEX; LOBE; MRI; PATHOLOGY; DEFICITS; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Vogeley, K Univ Bonn, Dept Psychiat, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 n, Germany
Citazione:
K. Vogeley et al., "Disturbed gyrification of the prefrontal region in male schizophrenic patients: A morphometric postmortem study", AM J PSYCHI, 157(1), 2000, pp. 34-39

Abstract

Objective: The goal was to test the hypothesis that abnormalities of gyrification are present in the prefrontal region of postmortem brains from schizophrenic patients. Method: The authors compared the prefrontal regions in brains from 24 schizophrenic patients and 24 normal comparison subjects. The gyrification index, the ratio of inner and outer surface contours, was measured bilaterally in three different slices from each brain. Area measurements of gray and white matter were studied separately by planimetric analysis in the same sections. In addition, a gray-to-white-matter ratio and an asymmetry coefficient were computed. Results: The mean gyrification index onthe right side was significantly higher in the male schizophrenic patientsthan in the comparison men. The gyrification index of the female patients was not significantly different from that of the female comparison subjects. Analysis of area measurements revealed no significant differences. Conclusions: As gyrification is an ontogenetic stable feature unaffected by atrophic processes during aging, the gyrification abnormalities of the prefrontal region provide further evidence of the importance of a neurodevelopmentalmechanism in the etiology of schizophrenia, at least in males.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:22:12