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Titolo:
Meta-analysis of regional brain volumes in schizophrenia
Autore:
Wright, IC; Rabe-Hesketh, S; Woodruff, PWR; David, AS; Murray, RM; Bullmore, ET;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Univ Manchester, Sch Psychiat & Behav Sci, Manchester M20 8LR, Lancs, England Univ Manchester Manchester Lancs England M20 8LR M20 8LR, Lancs, England Univ Cambridge, Cambridge, England Univ Cambridge Cambridge EnglandUniv Cambridge, Cambridge, England
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 1, volume: 157, anno: 2000,
pagine: 16 - 25
SICI:
0002-953X(200001)157:1<16:MORBVI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAY-MATTER VOLUME; FIRST-EPISODE SCHIZOPHRENIA; SUPERIOR TEMPORAL GYRUS; RESONANCE-IMAGING ABNORMALITIES; CHILDHOOD-ONSET SCHIZOPHRENIA; MONOZYGOTIC TWINS DISCORDANT; HIPPOCAMPAL VOLUME; VENTRICULAR ENLARGEMENT; PSYCHOTIC-PATIENTS; AFFECTIVE-DISORDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Wright, IC Inst Psychiat, Dept Psychol Med, De Crespigny Pk,Denmark Hill, London SE5 8AF, England Inst Psychiat De Crespigny Pk,Denmark Hill London England SE5 8AF
Citazione:
I.C. Wright et al., "Meta-analysis of regional brain volumes in schizophrenia", AM J PSYCHI, 157(1), 2000, pp. 16-25

Abstract

Objective: The authors' goal was to determine whether patients with schizophrenia differ from comparison subjects in regional brain volumes and whether these differences are similar in male and female subjects. Method: They conducted a systematic search for structural magnetic resonance imaging (MRI) studies of patients with schizophrenia that reported volume measurementsof selected cortical, subcortical, and ventricular regions in relation to comparison groups. They carried out a meta-analysis of the volumes of theseregions in the patients with schizophrenia and the comparison subjects using a random effects model; they also used random effects regression analysis to examine the influence of gender on effect sizes. Results: Fifty-eight studies were identified as suitable for analysis; these studies included 1,588 independent patients with schizophrenia. Assuming a volume of 100% in the comparison group, they found that the mean cerebral volume of the subjects with schizophrenia was smaller (98%), but the mean total ventricular volume of the subjects with schizophrenia was greater (126%). Relative to the cerebral volume differences, the regional volumes of the subjects with schizophrenia were 94% in the left and right amygdala, 94% in the left and 95% in the right hippocampus/amygdala, and 93% in the left and 95% in the rightparahippocampus. Relative to the global ventricular system differences, the largest differences in ventricular subdivisions were in the right and left body of the lateral ventricle, where the volumes of schizophrenic subjects were 116% and 116%, respectively. For most regions, effect size was not significantly related to gender, Conclusions: Regional structural differences in patients with schizophrenia include bilaterally reduced volume of medial temporal lobe structures. There is a need for greater integration of results from structural MRI studies to avoid redundant research activity.

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Documento generato il 21/01/20 alle ore 06:49:13