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Titolo:
Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
Autore:
Siscovick, DS; Raghunathan, TE; King, I; Weinmann, S; Bovbjerg, VE; Kushi, L; Cobb, LA; Copass, MK; Psaty, BM; Lemaitre, R; Retzlaff, B; Knopp, RH;
Indirizzi:
Washington Univ, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USAWashington Univ Seattle WA USA 98101 Hlth Res Unit, Seattle, WA 98101 USA Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA Univ Michigan, Inst Social Res, Ann Arbor, MI USA Univ Michigan Ann ArborMI USA higan, Inst Social Res, Ann Arbor, MI USA Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 demiol, Minneapolis, MN 55455 USA Washington Univ, Dept Epidemiol, Seattle, WA 98101 USA Washington Univ Seattle WA USA 98101 ept Epidemiol, Seattle, WA 98101 USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 1, volume: 71, anno: 2000, supplemento:, S
pagine: 208S - 212S
SICI:
0002-9165(200001)71:1<208S:DIOLNP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; VENTRICULAR-FIBRILLATION THRESHOLD; FISH CONSUMPTION; MARMOSET MONKEY; MORTALITY; OIL; PHYSICIANS; MODULATION; CHANNELS;
Keywords:
n-3 fatty acids; diet; risk factors; arrythmia; sudden death; cardiac arrest; ischemic heart disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Siscovick, DS Washington Univ, Dept Med, Cardiovasc Hlth Res Unit, Metropolitan Pk 2 Bldg,Suite 14360,1730 Minor Ave, Seattle, WA 98101 USA Washington Univ Metropolitan Pk 2 Bldg,Suite 14360,1730 Minor Ave Seattle WA USA 98101
Citazione:
D.S. Siscovick et al., "Dietary intake of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest", AM J CLIN N, 71(1), 2000, pp. 208S-212S

Abstract

Whether the dietary intake of long-chain n-3 polyunsaturated fatty acids (PUFAs) from seafood reduces the risk of ischemic heart disease remains a source of controversy, in part because studies have yielded inconsistent findings. Results from experimental studies in animals suggest that recent dietary intake of long-chain n-3 PUFAs, compared with saturated and monounsaturated fats, reduces vulnerability to ventricular fibrillation, a life-threatening cardiac arrhythmia that is a major cause of ischemic heart disease mortality. Until recently, whether a similar effect of long-chain n-3 PUFAs from seafood occurred in humans was unknown. We summarize the findings from a population-based case-control study that showed that the dietary intake of long-chain n-3 PUFAs from seafood, measured both directly with a questionnaire and indirectly with a biomarker, is associated with a reduced risk ofprimary cardiac arrest in humans. The Endings also suggest that I) compared with no seafood intake, modest dietary intake of long-chain n-3 PUFAs from seafood (equivalent to 1 fatty fish meal/wk) is associated with a reduction in the risk of primary cardiac arrest; 2) compared with modest intake, higher intakes of these fatty acids are not associated with a further reduction in such risk; and 3) the reduced risk of primary cardiac arrest may be mediated, at least in part, by the effect of dietary n-3 PUFA intake on cell membrane fatty acid composition. These findings also may help to explain the apparent inconsistencies in earlier studies of long-chain n-3 PUFA intake and ischemic heart disease.

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Documento generato il 03/12/20 alle ore 05:18:08