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Titolo:
NEONATAL GAMMA-RAY IRRADIATION IMPAIRS LEARNING AND MEMORY OF AN OLFACTORY ASSOCIATIVE TASK IN ADULT-RATS
Autore:
CHAILLAN FA; DEVIGNE C; DIABIRA D; KHRESTCHATISKY M; ROMAN FS; BENARI Y; SOUMIREUMOURAT B;
Indirizzi:
UNIV AIX MARSEILLE 1,IBHOP,CNRS,URA 372,LAB NEUROBIOL COMPORTEMENTS,TRAVERSE CHARLES SUSINI F-13388 MARSEILLE 13 FRANCE UNIV AIX MARSEILLE 1,IBHOP,CNRS,URA 372,LAB NEUROBIOL COMPORTEMENTS F-13388 MARSEILLE 13 FRANCE INSERM,U29,LAB NEUROBIOL & PHYSIOPATHOL DEV F-75014 PARIS FRANCE
Titolo Testata:
European journal of neuroscience
fascicolo: 5, volume: 9, anno: 1997,
pagine: 884 - 894
SICI:
0953-816X(1997)9:5<884:NGIILA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL SYSTEM; PIRIFORM CORTEX; LESIONS; TERM; BULB; INTERFERENCE; FACILITATION; POTENTIATION; ORGANIZATION; AMNESIA;
Keywords:
GAMMA-IRRADIATION; HIPPOCAMPAL FORMATION; PIRIFORM CORTEX; OLFACTORY BULBS; OLFACTORY ASSOCIATIVE TASK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
F.A. Chaillan et al., "NEONATAL GAMMA-RAY IRRADIATION IMPAIRS LEARNING AND MEMORY OF AN OLFACTORY ASSOCIATIVE TASK IN ADULT-RATS", European journal of neuroscience, 9(5), 1997, pp. 884-894

Abstract

Adult neonatally gamma-irradiated rats were compared with control animals in a non-spatial olfactory associative task using two different procedures. Irradiation induced a clear reduction in the total mean area of the olfactory bulbs and hippocampus but not of the orbital prefrontal cortex, diagonal band and cell layers of the entorhinal and piriform cortex. The gamma-irradiation affected the granule cells of the olfactory bulbs and differentially altered the cell layers of the subfields of the ammonic fields and the dorsal and ventral blades of the dentate gyrus. In the CA1 ammonic field, dorsal and ventral blades of thedentate gyrus, the cellular loss was significant in comparison with control adult rats. The behavioural data indicated that irradiated ratswere deeply disturbed in learning the odour-reward association, and substantially impaired in a reversal experiment, but not in the discrimination of the odours per se. The cellular loss in the olfactory bulbs, in the CA1 and in the ventral blade of the gyrus dentatus was positively correlated with the deficit in behavioural performance. The data support the findings that the hippocampal system participates in the odour-reward associations and facilitates the long-term storage of associations after learning is achieved in this olfactory associative task.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:42:22