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Titolo:
Transgenesis in large domestic species: future development for milk modification
Autore:
Pintado, B; Gutierrez-Adan, A;
Indirizzi:
Inia, Dept Reprod Anim & Conservac Recursos Zoogenet, Madrid 28040, Spain Inia Madrid Spain 28040 Conservac Recursos Zoogenet, Madrid 28040, Spain
Titolo Testata:
REPRODUCTION NUTRITION DEVELOPMENT
fascicolo: 5-6, volume: 39, anno: 1999,
pagine: 535 - 544
SICI:
0926-5287(199909/12)39:5-6<535:TILDSF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMARY-GLAND EXPRESSION; MEDIATED GENE-TRANSFER; NEUTRALIZING ANTIBODIES; FETAL FIBROBLASTS; MOUSE EMBRYOS; PROTEIN GENES; DAIRY-CATTLE; LARGE-SCALE; MICE; ANIMALS;
Keywords:
transgenesis; milk; dairy industry; cattle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Pintado, B Inia, Dept Reprod Anim & Conservac Recursos Zoogenet, CarreteraCoruna Km 5,9, Madrid 28040, Spain Inia Carretera Coruna Km 5,9 Madrid Spain 28040 d 28040, Spain
Citazione:
B. Pintado e A. Gutierrez-Adan, "Transgenesis in large domestic species: future development for milk modification", REPROD NUTR, 39(5-6), 1999, pp. 535-544

Abstract

The present review has two goals. First, to Offer an overview of recent advances in the technical strategies applied to the production of transgenic large domestic animals, and second, to review how transgenic technology canbe applied to the modification of milk composition. Transgenic sheep and cattle obtained through nuclear transfer are now a reality, opening up a means of ruminant transgenic production with an efficiency that entitles us toconsider it a serious alternative to microinjection. Nuclear transfer alsoconsistently reduces the time needed to establish a transgenic production herd, and what is more important, it opens up the way to homologous recombination in large species, which at the moment is restricted to mice. Other interesting technological contributions have also taken place lately, some of them towards the modification of the male germ line, and others developing viral vectors with the ability to alter the genetic information of animals. The simplification of the methodology and the consistent reduction of the time needed to carry out a transgenic experiment will allow us to test several hypotheses directed at the modification of milk components. This may help towards the application of transgenic technology in the dairy industry, which unlike pharmaceutical companies, has been somehow reluctant over these approaches. (C) Inra/Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:16:02