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Titolo:
Risk factors for pre-eclampsia
Autore:
Dumont, A; Merviel, P; Berkane, N; Gaudet, R; Uzan, S;
Indirizzi:
Hop Tenon, Serv Gynecol Obstet, Unite Propre Rech Physiol Implantat & Dev 2396, F-75020 Paris, France Hop Tenon Paris France F-75020 plantat & Dev 2396, F-75020 Paris, France
Titolo Testata:
PRESSE MEDICALE
fascicolo: 39, volume: 28, anno: 1999,
pagine: 2189 - 2196
SICI:
0755-4982(199912)28:39<2189:RFFP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
FRE
Soggetto:
LOW-DOSE ASPIRIN; PREGNANCY-INDUCED HYPERTENSION; INTRAUTERINE GROWTH-RETARDATION; HUMAN CHORIONIC-GONADOTROPIN; HEALTHY NULLIPAROUS WOMEN; INCREASED PLASMA-LEVELS; DOPPLER ULTRASOUND; SEVERE PREECLAMPSIA; UTEROPLACENTAL CIRCULATION; EARLY PREDICTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Uzan, S Hop Tenon, Serv Gynecol Obstet, Unite Propre Rech Physiol Implantat & Dev 2396, 4 Rue Chine, F-75020 Paris, France Hop Tenon 4 Rue Chine Paris France F-75020 F-75020 Paris, France
Citazione:
A. Dumont et al., "Risk factors for pre-eclampsia", PRESSE MED, 28(39), 1999, pp. 2189-2196

Abstract

Patient-related factors: Multiparous patients with a past history of severe preeclampsia are a high risk population which should be identified early in pregnancy. Selection on this criterion alone is however insufficient forlarge scale screening and prevention because most of the susceptible womenare nulliparous. Search for a particular familial or personal history of vascular disorders can be helpful. The usefulness of blood pressure measurements during the second trimester has not been proven. Markers: There is a significant association between pre-eclampsia and a large number of biological markers. No one assay can however fulfill the requirements for effective early screening because sensitivity is too low or the rate of false positives is too high, or because the examination is too invasive or costly. Doppler anomalies: Doppler exploration of the uterine arteries at 20 to 24weeks gestation offers satisfactory sensitivity and specificity but the positive predictive value is low. Persistence of a bilateral notch beyond 24 weeks considerably limits the number of false positives. More than half of the patients with this anomaly will develop hypertension during pregnancy. While no one marker fulfills ail the prerequisites for effective screening,a combination of several tests may be useful. hCG assay during the second trimester in association with Doppler exploration of the uterine arteries appears to be a promising combination. Prevention: Starting with these markers or risk factors, the goal is to develop a prevention scheme using low-dose aspirin, the only evidence-based preventive treatment to date. Further trials are required to test simultaneously the predictive value and impact (versus placebo) of proposed strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:29:55