Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Conditioned suppression with cocaine as the unconditioned stimulus
Autore:
Schindler, CW; Thorndike, EB; Ma, JD; Goldberg, SR;
Indirizzi:
NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, NIH,Intramural Res Program, Baltimore, MD 21224 USA NIDA Baltimore MD USA 21224 tramural Res Program, Baltimore, MD 21224 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 65, anno: 2000,
pagine: 83 - 89
SICI:
0091-3057(200001)65:1<83:CSWCAT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELF-ADMINISTERED COCAINE; INHIBITION; DRUGS; RATS;
Keywords:
cocaine; conditioned suppression; classical conditioning; interstimulus interval; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Schindler, CW NIDA, Preclin Pharmacol Sect, Behav Neurosci Branch, NIH,Intramural Res Program, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA NIDA 5500 Nathan Shock Dr Baltimore MD USA 21224 D 21224 USA
Citazione:
C.W. Schindler et al., "Conditioned suppression with cocaine as the unconditioned stimulus", PHARM BIO B, 65(1), 2000, pp. 83-89

Abstract

A conditioned-suppression procedure was used to study drug conditioning using cocaine as the unconditioned stimulus (UCS). Rats were first trained tonose poke for food-reinforcement during daily 60-min sessions. At least 1 week following jugular vein catheterization, a 5-min tone-light compound stimulus was presented 30 min into the food-reinforcement session. Two minutes after the onset of the stimulus, either 0 (saline), 1.0, 3.0 or 5.6 mg/kgcocaine, was administered IV to separate groups of rats. For another group, the stimulus was presented, and the 5.6 mg/kg dose of cocaine was injected in an unpaired fashion (i.e., at different times). After 5 days of training a test was given with the tone-light stimulus presented alone. No disruption of responding during the tone-light stimulus was observed in the saline and 1.0 mg/kg cocaine groups or for the unpaired group. When the tone-light stimulus was paired with 5.6 mg/kg cocaine; however, it produced nearly a 50% reduction in responding, which then gradually extinguished when the stimulus was presented alone for 5 days. The 3.0 mg/kg cocaine group produced intermediate suppression. When the tone-light compound stimulus was shortened to 70 s and the interstimulus interval (ISI) was 0, 30, or 60 s in three separate groups of rats, the most robust conditioned suppression was observed at the 60 s ISI. Therefore, the conditioned suppression procedure, using 3.0 or 5.6 mg/kg IV cocaine doses as the UCS, produced robust conditioning effects comparable to other drugs and more conventional reinforcers. The conditioned suppression procedure may be a useful model for studying the classically conditioned effects of cocaine. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:16:21