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Titolo:
Cardiac loading conditions modify the ventricular repolarization in conscious dogs with heart failure
Autore:
Victor, F; Carre, F; Gout, B; Jean, J; MPolesha, E; Mabo, P; Bril, A;
Indirizzi:
SmithKline Beecham Labs Pharmaceut, Cardiac Res Dept, F-35762 St Gregoire,France SmithKline Beecham Labs Pharmaceut St Gregoire France F-35762 ire,France Univ Hosp, Dept Physiol, Dept Cardiol, F-35043 Rennes, France Univ Hosp Rennes France F-35043 ol, Dept Cardiol, F-35043 Rennes, France Hop Lariboisiere, INSERM U127, F-75010 Paris, France Hop Lariboisiere Paris France F-75010 INSERM U127, F-75010 Paris, France
Titolo Testata:
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
fascicolo: 3, volume: 439, anno: 2000,
pagine: 217 - 226
SICI:
0031-6768(200001)439:3<217:CLCMTV>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MECHANOELECTRICAL FEEDBACK; QT INTERVAL; BAINBRIDGE REFLEX; SUDDEN-DEATH; TACHYCARDIA; STRETCH; CARDIOMYOPATHY; CONTRACTILITY; ARRHYTHMIAS; MODULATION;
Keywords:
electrogram; QT interval; mechanoelectric feedback; volume loading; rapid pacing dilated cardiomyopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Bril, A SmithKline Beecham Labs Pharmaceut, Cardiac Res Dept, 4 Rue Chesnay Beauregard,BP 58, F-35762 St Gregoire, France SmithKline Beecham Labs Pharmaceut 4 Rue Chesnay Beauregard,BP 58 St Gregoire France F-35762
Citazione:
F. Victor et al., "Cardiac loading conditions modify the ventricular repolarization in conscious dogs with heart failure", PFLUG ARCH, 439(3), 2000, pp. 217-226

Abstract

Changes in myocardial loading conditions influence the ventricular action potential via mechanoelectric feedback, a mechanism impaired in pathology. In vivo the QT interval of the electrocardiogram which reflects the action potential duration allows appropriate determination of its modifications. The effects of changes in cardiac loading conditions (load reduction with trinitrin volume loading with Plasmion) On regional function and ventricular local electrogram were investigated in conscious dogs before (control) and after 4 weeks of rapid pacing (dilated cardiomyopathy, DCM). In controls both interventions increased heart rate. Trinitrin in creased end-diastolic wall thickness (EDWth, P<0.001) and reduced absolute QT interval duration (P<0.05). Plasmion decreased EDWth (P<0.001) and increased left ventricular end diastolic pressure (LVEDP, P<0.001) without QT interval alteration. However, the corrected QT interval was unchanged in both interventions. In DCM,trinitrin did not change the QT interval. Plasmion increased LVEDP (P<0.01) and prolonged QT and corrected QT intervals (P<0.01) despite the tachycardia. In controls the changes in cardiac loading conditions did not modify the QT interval, suggesting intact endogenous regulation of repolarization. The impaired adaptation observed in DCM contributed to an increase in QT interval following volume loading. In this model, a prolonged repolarization after abrupt volume loading may result from enhanced or disclosed mechanoelectric feedback.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:11:37