Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of cathepsin B and cystatin C in the human adenohypophysis and in pituitary adenomas
Autore:
Yoshimura, K; Tsuchida, T; Kawamoto, K;
Indirizzi:
Kansai Med Univ, Dept Neurosurg, Moriguchi, Osaka 570, Japan Kansai Med Univ Moriguchi Osaka Japan 570 rg, Moriguchi, Osaka 570, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 1, volume: 7, anno: 2000,
pagine: 27 - 31
SICI:
1021-335X(200001/02)7:1<27:EOCBAC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-TRACE; IMMUNOCYTOCHEMICAL LOCALIZATION; CYSTEINE PROTEINASES; LACTOTROPH CELLS; RENIN; RAT; INHIBITOR; PRORENIN; ENZYME; GLAND;
Keywords:
cathepsin B; cystatin C; adenohypophysis; pituitary adenoma; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuchida, T Kansai Med Univ, Dept Neurosurg, 10-15 Fumizonocho, Moriguchi,Osaka 570, Japan Kansai Med Univ 10-15 Fumizonocho Moriguchi Osaka Japan 570 an
Citazione:
K. Yoshimura et al., "Expression of cathepsin B and cystatin C in the human adenohypophysis and in pituitary adenomas", ONCOL REP, 7(1), 2000, pp. 27-31

Abstract

The localization of cathepsin B, a potential promoter of prolactin (PRL) release via extra renal renin-angiotensin system in the adenohypophysis, andits inhibitor cystatin C in the human adenohypophysis and in pituitary adenomas were examined using single and dual immunohistochemical staining. In the adenohypophysis, cathepsin B was expressed in about 50% of the ACTH-producing cells, and in 5% or less of the GH- and PRL-producing cells. In contrast, cystatin C was expressed in about 70% of the GH-and PRL-producing cells, but in only 5% or less of the ACTH-producing cells. PRL-producing adenomas strongly expressed cathepsin B, but only weakly expressed cystatin C, apattern of staining contrary to the expression in normal PRL-producing cells. The above results suggest that cathepsin B may play a role in promotingPRL release especially in PRL-producing adenomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:40:23