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Titolo:
Lithium modulates desensitization of the glutamate receptor subtype GluR3 in Xenopus oocytes
Autore:
Karkanias, NB; Papke, RL;
Indirizzi:
Univ Florida, Coll Med, Dept Neurosci, JH Miller Hlth Ctr, Gainesville, FL32610 USA Univ Florida Gainesville FL USA 32610 Hlth Ctr, Gainesville, FL32610 USA Univ Florida, Coll Med, Dept Pharmacol & Therapeut, JH Miller Hlth Ctr, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Hlth Ctr, Gainesville, FL 32610 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 277, anno: 1999,
pagine: 153 - 156
SICI:
0304-3940(199912)277:3<153:LMDOTG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY SYNAPTIC TRANSMISSION; KAINATE RECEPTORS; NMDA RECEPTORS; CONCANAVALIN-A; AMPA; CHANNELS; CYCLOTHIAZIDE; POTENTIATION;
Keywords:
Xenopus oocyte; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate; desensitization; aniracetam; glutamate; kainate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Papke, RL Univ Florida, Coll Med, Dept Neurosci, JH Miller Hlth Ctr, Box 100267, Gainesville, FL 32610 USA Univ Florida Box 100267 Gainesville FL USA32610 e, FL 32610 USA
Citazione:
N.B. Karkanias e R.L. Papke, "Lithium modulates desensitization of the glutamate receptor subtype GluR3 in Xenopus oocytes", NEUROSCI L, 277(3), 1999, pp. 153-156

Abstract

Analysis of splice variants and site-directed mutants of the AMPA receptorGluR3 expressed in Xenopus oocytes has shown that lithium produces a largepotentiation of the GluR3 flop splice variant and suggested that lithium might inhibit rapid desensitization, which is characteristic of this receptor (Karkanias, N. and Papke, R., Subtype-specific effects of lithium on glutamate receptor function. J. Neurophysiol.,81 (1999) 1506-1512). We now showthat mutation of the 769R/G: desensitization site (Lomeli, H.M.J., Melcher, T., Hoger, T., Geiger, J.R., Kuner, T., Monyer, H., Higuchi, M.B.A, and Seeburg, P.H, Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science, 9(266) (1994) 1709-1713) greatly attenuates the lithium-induced potentiation of GluR3. Additionally, experiments with the non-desensitizing site-directed mutant GluR3(L507Y) (Stern-Bach, Y., Russo, S., Neuman, M. and Rosenmund, C., A point mutation in the glutamate bindingsite blocks desensitization of AMPA receptors. Neuron, 21 (1998) 907-918) further confirms that lithium enhances GluR3 responses by reducing desensitization, since lithium's effects are reversed in this mutant. Lithium's effects on GluR3 desensitization are distinct from the effects of aniracetam on desensitization. Specifically, aniracetam, which potentiates wild-type AMPA receptors, is ineffective on the non-desensitizing GluR3(L507Y) mutant, but has synergistic effects with lithium on wild-type receptors. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:26:58